Antimicrobial wash

Abstract

A method for detaching, removing or otherwise disrupting bacteria or biofilm by applying with pressure an antimicrobial wash. The antimicrobial wash contains a biguanide compound or mixtures thereof.

1 - 11 . (canceled) 
     
     
         12 . A method for treating otitis media and other bacterial ear conditions, which method comprises:
 applying with pressure an antimicrobial wash comprising a biguanide compound or mixtures thereof to a treatment site within an ear; and   detaching, removing or otherwise disrupting bacteria or biofilm within the ear using the antimicrobial wash.   
     
     
         13 . The method according to  claim 12 , wherein the pressure is about 30,000 Pascal to about 480,000 Pascal. 
     
     
         14 . The method according to  claim 12 , wherein the biguanide is a polybiguanide. 
     
     
         15 . The method according to  claim 12 , wherein the biguanide is about 0.005 wt % to about 0.5 wt % of the antimicrobial wash. 
     
     
         16 . The method according to  claim 12 , wherein the biguanide is about 0.025 wt % to about 0.2 wt % of the antimicrobial wash. 
     
     
         17 . The method according to  claim 12 , further comprising applying to the treatment site a protective layer of a polymeric film-forming medical sealant after detaching, removing or otherwise disrupting the bacteria or tissue. 
     
     
         18 . The method according to  claim 12 , wherein applying with pressure the antimicrobial wash causes greater than 1-log order reduction in a population of one or more of  Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis, Escherichia coli Staphylococcus pneumonia, Haemophilus influenzae  or  Moraxella catarrhalis  bacteria. 
     
     
         19 . The method according to  claim 12 , wherein applying with pressure the antimicrobial wash causes greater than a 2-log order reduction in a population of one or more  Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis, Escherichia coli, Staphylococcus pneumonia, Haemophilus influenzae  or  Moraxella catarrhalis  bacteria. 
     
     
         20 . The method according to  claim 12 , wherein applying with pressure the antimicrobial wash causes a greater than a 3-log order reduction in a population of one or more  Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus pneumonia, Haemophilus influenzae  or  Moraxella catarrhalis  bacteria. 
     
     
         21 . The method according to  claim 12 , wherein the antimicrobial wash is non-ciliotoxic. 
     
     
         22 . A kit for treating otitis media and other bacterial ear conditions comprising:
 a device that can apply solution with pressure; the device containing an antimicrobial wash comprising a biguanide solution; and   printed instructions describing proper use of the antimicrobial wash for treating otitis media or other bacterial ear conditions.   
     
     
         23 . The kit according to  claim 22 , wherein the device is capable of applying the antimicorobial wash at a pressure of about 30,000 Pascal to about 480,000 Pascal. 
     
     
         24 . The kit according to  claim 22 , wherein the biguanide is a polybiguanide. 
     
     
         25 . The kit according to  claim 24 , wherein the polybiguanide is a polyhexamethylene biguanide, salts thereof or combinations thereof. 
     
     
         26 . The kit according to  claim 22 , wherein the biguanide is about 0.005 wt % to about 0.5 wt % of the antimicrobial wash. 
     
     
         27 . The kit according to  claim 22 , wherein the antimicrobial wash is substantially free of surfactants. 
     
     
         28 . The kit according to  claim 22 , wherein the antimicrobial wash is non-cyliotoxic. 
     
     
         29 . The kit according to  claim 22 , wherein the antimicrobial wash has a cytotoxicity score of 3 or less as measured by ISO10993-5, Biological Evaluation of Medical Devices—Part 5. 
     
     
         30 . The kit according to  claim 22 , further comprising sterilized packaging containing the antimicrobial wash. 
     
     
         31 . A method for treating bacterial ear, nose, or throat conditions, which method comprises:
 applying with pressure an antimicrobial wash to a treatment site within an ear, a nose, a sinus, or a throat, wherein the antimicrobial wash is non-ciliotoxic and comprises a biguanide compound or mixtures thereof.