KIT FOR IN VITRO OR EX VIVO MEASUREMENT OF THE EXPRESSION OF sCD127 IN A BIOLOGICAL SAMPLE

Abstract

A kit for in vitro or ex vivo measurement of the expression of solubleCD127 in a biological sample, including: tools or reagents for measuring the expression of solubleCD127 in the biological sample; and a positive control sample, which is a sample calibrated to contain the quantity of sCD127 that corresponds to the mean quantity measured in a pool of samples from patients who have been subjected to an insult or to an infection generating a systemic inflammatory response who are known to have survived, and/or a negative control sample, which is a sample calibrated to contain the quantity of solubleCD127 that corresponds to the mean quantity measured in a pool of samples from patients who have been subjected to an insult or to an infection generating a systemic inflammatory response who are known not to have survived.

1 . A kit for in vitro or ex vivo measurement of the expression of solubleCD127 in a biological sample, comprising:
 tools or reagents for measuring the expression of solubleCD127 in the biological sample; and   a positive control sample, which is a sample calibrated to contain the quantity of sCD127 that corresponds to the mean quantity measured in a pool of samples from patients who have been subjected to an insult or to an infection generating a systemic inflammatory response who are known to have survived, and/or a negative control sample, which is a sample calibrated to contain the quantity of solubleCD127 that corresponds to the mean quantity measured in a pool of samples from patients who have been subjected to an insult or to an infection generating a systemic inflammatory response who are known not to have survived.   
     
     
         2 . The kit according to  claim 1 , wherein the tools or reagents allow the detection and/or the quantification of solubleCD127 expression. 
     
     
         3 . The kit according to  claim 2 , wherein the tools or reagents allow the detection and/or the quantification of solubleCD127 expression, at a protein level. 
     
     
         4 . The kit according to  claim 3 , wherein the tools or reagents are anti-solubleCD127 antibodies. 
     
     
         5 . The kit according to  claim 3 , wherein the tools or reagents are monoclonal anti-solubleCD127 antibodies. 
     
     
         6 . The kit according to  claim 1 , wherein the patients are patients with sepsis, or severe sepsis. 
     
     
         7 . The kit according to  claim 1 , wherein the patients are patients in septic shock. 
     
     
         8 . The kit according to  claim 7 , wherein the biological samples of the pool are taken within 2 days, or at day 2 after septic shock. 
     
     
         9 . The kit according to  claim 7 , wherein the biological samples of the pool are taken within the day after septic shock, or one day after septic shock.