US2020253942A1PendingUtilityA1

Therapeutic drug for ectopic ossification having mechanism to inhibit par1

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Assignee: UNIV KUMAMOTO NAT UNIV CORPPriority: Nov 20, 2015Filed: Nov 17, 2016Published: Aug 13, 2020
Est. expiryNov 20, 2035(~9.3 yrs left)· nominal 20-yr term from priority
Inventors:Takumi EraTakayuki Kiboku
A61K 31/443G01N 33/6887A61P 19/08A61K 45/00A61P 43/00
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Claims

Abstract

A pathological mechanism in FOP patients is further revealed, and development of a novel therapeutic drug, therapeutic method, diagnostic method, etc. utilizing an obtained finding is provided. The inventors have found a novel finding that in FOP, ectopic ossification, which occurs by an inflammation due to an injury, etc., is mediated by PAR1 to occur. From this finding, the inventors completed the present invention relating to a drug, etc. characterized by suppressing ectopic ossification in FOP by inhibiting PAR1.

Claims

exact text as granted — not AI-modified
1 . A drug for ectopic ossification to treat or prevent ectopic ossification by inhibiting PAR1. 
     
     
         2 . The drug for ectopic ossification according to  claim 1 , wherein PAR1 is inhibited by an antagonist of PAR1. 
     
     
         3 . The drug for ectopic ossification according to  claim 2 , wherein the antagonist of PAR1 is ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(1E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethen-1-yl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate or a salt thereof. 
     
     
         4 . The drug for ectopic ossification according to  claim 1 , wherein ectopic ossification is a symptom caused by fibrodysplasia ossificans progressiva. 
     
     
         5 . A method for treating or preventing ectopic ossification by using a drug for ectopic ossification according to  claim 1 . 
     
     
         6 . The drug for ectopic ossification according to  claim 2 , wherein ectopic ossification is a symptom caused by fibrodysplasia ossificans progressiva. 
     
     
         7 . The drug for ectopic ossification according to  claim 3 , wherein ectopic ossification is a symptom caused by fibrodysplasia ossificans progressiva. 
     
     
         8 . A method for treating or preventing ectopic ossification by using a drug for ectopic ossification according to  claim 2 . 
     
     
         9 . A method for treating or preventing ectopic ossification by using a drug for ectopic ossification according to  claim 3 . 
     
     
         10 . A method for treating or preventing ectopic ossification by using a drug for ectopic ossification according to  claim 4 .

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