Agent for controlling cells constituting cancer microenvironment or inflammatory microenvironment

Abstract

An agent according to the present invention comprises as an effective component any of (1) disulfiram, diethyldithiocarbamate, or a metal complex of diethyldithiocarbamate; (2) a pharmaceutically acceptable salt of (1); or (3) a solvate of (1) or (2), and is used for inhibition of interaction between CR2B or CCR5 and FROUNT protein, inhibition of macrophages, control of cells constituting a cancer microenvironment or inflammatory microenvironment, or enhancement of anticancer activity of an anticancer drug. It is also possible to provide a compound with a reduced side effect and an increased pharmacological effect by identifying a disulfiram derivative having a lower aldehyde dehydrogenase-inhibiting activity and a higher FROUNT-inhibiting activity among derivatives prepared by structural modification of disulfiram.

1 . A method comprising inhibiting macrophages in a subject in need thereof by administering an effective amount of any of the following (1) to (3) to the subject:
 (1) disulfiram, diethyldithiocarbamate, or a metal complex of diethyldithiocarbamate;   (2) a pharmaceutically acceptable salt of (1);   (3) a solvate of (1) or (2),   wherein said subject is a patient with inflammatory disease.