US2020237888A1PendingUtilityA1

Compositions comprising recombinant probiotic bacteria and methods of use thereof

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Assignee: VEDANTAM GAYATRIPriority: Jan 23, 2015Filed: Mar 9, 2020Published: Jul 30, 2020
Est. expiryJan 23, 2035(~8.5 yrs left)· nominal 20-yr term from priority
Inventors:Gayatri VedantamVirinchipuram K. ViswanathanMichael A. Mallozzi
A61K 35/747A61P 31/04A61K 2039/523A61K 39/08
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Claims

Abstract

The invention features probiotic bacteria expressing Clostridium difficile SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . An isolated polypeptide comprising a bacterial secretion signal,  C. difficile  SlpA variable domain, and  Lactobacillus  SlpA cell wall binding domain.

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