US2020237685A1PendingUtilityA1

Beta-Hydroxyketones as topical active ingredients for the prevention or treatment of photodermatoses

Assignee: MERCK PATENT GMBHPriority: Nov 27, 2015Filed: Apr 15, 2020Published: Jul 30, 2020
Est. expiryNov 27, 2035(~9.3 yrs left)· nominal 20-yr term from priority
A61P 17/00A61K 31/12
51
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Claims

Abstract

The present invention relates to specific β-hydroxyketones of the formula (I) for use in the prevention and/or treatment of photodermatoses and to the use of specific β-hydroxyketones of the formula (I) as active ingredient in typical compositions for the prevention and/or non-therapeutic treatment of photodermatoses, in particular of polymorphic light eruption.

Claims

exact text as granted — not AI-modified
1 .- 8 . (canceled) 
     
     
         9 . A method of inhibiting inflammation, comprising administering to a host in need thereof a compound that is 3-(4-tert-butylphenyl)-3-hydroxy-1-(4-methoxyphenyl)propan-1-one, 1-(4-tert-butylphenyl)-3-hydroxy-3-(4-methoxyphenyl)propan-1-one or a mixture thereof. 
     
     
         10 . A method of inhibiting transcription factor NF-κB, comprising administering to a host in need thereof a compound that is 3-(4-tert-butylphenyl)-3-hydroxy-1-(4-methoxyphenyl)propan-1-one, 1-(4-tert-butylphenyl)-3-hydroxy-3-(4-methoxyphenyl)propan-1-one or a mixture thereof.

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