US2020224040A1PendingUtilityA1

Process for producing an antibacterial coating composition for implants

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Assignee: BRASSELER GMBH & CO KG GEBPriority: Oct 2, 2015Filed: Jan 28, 2020Published: Jul 16, 2020
Est. expiryOct 2, 2035(~9.2 yrs left)· nominal 20-yr term from priority
Inventors:Henning MenzelMarco WassmannSebastian StelljesMeike StieschAndreas Winkel
A61L 27/54A61F 2310/00485A61F 2310/00401A61L 2300/404C09D 5/14A61F 2310/00407A61F 2310/00544A61F 2/02A61F 2310/0097C09D 151/08
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Claims

Abstract

A process for producing an antibacterial coating composition for implants. The process includes the steps i) reaction of a monomer A which is based on (meth)acrylic acid and contains at least one epoxide with a polyguanidine by reaction of an amino group of the polyguanidine with the epoxide to give a (meth)acrylic acid-polyguanidine macromolecule and ii) polymerization of the (meth)acrylic acid-polyguanidine macromolecule with a monomer B which contains at least one polymerizable double bond and at least one phosphonate group by free-radical polymerization of the (meth)acrylic acid unit and the double bond.

Claims

exact text as granted — not AI-modified
1 - 13 . (canceled) 
     
     
         14 . A process for producing an antibacterial coating composition for implants, which comprises the steps of:
 reaction of a monomer A which is based on (meth)acrylic acid and contains an epoxide with a polyguanidine by reaction of an amino group of the polyguanidine with the epoxide to give a (meth)acrylic acid-polyguanidine macro-molecule having a (meth)acrylic acid unit; and   polymerization of the (meth)acrylic acid-polyguanidine macromolecule with a monomer B which contains a polymerizable double bond and at least one phosphonate group by free-radical polymerization of the (meth)acrylic acid unit and the polymerizable double bond.   
     
     
         15 . The process according to  claim 14 , wherein the monomer A is 2,3-epoxypropyl methacrylate. 
     
     
         16 . The process according to  claim 14 , wherein the monomer B is diethyl (4-vinylbenzyl)phosphonate, 2-(dimethoxyphosphoryl)ethyl methacrylate or 2-(dimethoxyphosphoryl)methyl methacrylate. 
     
     
         17 . The process according to  claim 14 , wherein the polyguanidine is poly-2-(2-ethoxy)ethoxyethylguanidine hydrochloride. 
     
     
         18 . The process according to  claim 14 , wherein the polyguanidine is prepared by reaction of guanidine hydrochloride with 1,2-bis(2-aminoethoxy)ethane and has at least one of the following formulae: 
       
         
           
           
               
               
           
         
         where n is an integer in the range from 2 to 10. 
       
     
     
         19 . The process according to  claim 17 , wherein a molecular weight of the polyguanidine is from 800 to 1300 g/mol. 
     
     
         20 . The process according to  claim 14 , wherein a proportion of the monomer B based on the antibacterial coating composition is about 67 mol %. 
     
     
         21 . The antibacterial implant coating composition produced by a process according to  claim 14 . 
     
     
         22 . The process according to  claim 18 , where n is an integer in a range from 3 to 6. 
     
     
         23 . The process according to  claim 18 , where n is 5.

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