Anti-MCAM Antibodies And Associated Methods Of Use

Abstract

Described herein are anti-MCAM antibodies and antigen binding fragments thereof that are capable of inhibiting the interaction between MCAM and its ligand, a protein comprising a laminin α-4 chain. These anti-MCAM antibodies and antigen binding fragments thereof may be useful for, for example, treating inflammatory conditions characterized by the infiltration of MCAM-expressing cells into a site of inflammation in the body.

1 - 61 . (canceled) 
     
     
         62 . An antibody specifically binding to human MCAM of SEQ ID NO: 11 comprising a heavy chain comprising a heavy chain variable region of SEQ ID NO: 119 and a heavy chain constant region of human IgG1 isotype, and a light chain comprising a light chain variable region of SEQ ID NO: 123 and a light chain kappa constant region. 
     
     
         63 . The antibody of  claim 62  expressed from a CHO cell. 
     
     
         64 . A pharmaceutical composition comprising the antibody of  claim 62  and a physiologically acceptable carrier. 
     
     
         65 . A method of treating a human subject having multiple sclerosis comprising administering the antibody of  claim 62  to the human subject thereby treating the multiple sclerosis.