Use of polyphenol containing sugar cane extracts for preventing, improving or treating a skin condition

Abstract

The present disclosure is in the field of the prevention, improvement or treatment of skin conditions, for example skin conditions associated with skin aging and/or skin pigmentation and/or wound healing and/or psoriasis and/or acne. The disclosure provides extracts derived from sugar cane comprising polyphenols for the prevention, improvement or treatment of skin conditions, including skin conditions associated with skin aging and/or skin pigmentation and/or wound healing and/or psoriasis and/or acne.

1 . A method for preventing, improving or treating a skin condition in a subject, the method comprising topical or injection administration of a composition comprising from about 0.05 wt % to about 50 wt % of an extract derived from sugar cane to the subject, the extract comprising from about 10 catechin equivalent (CE) g/L to about 50 CE g/L of polyphenols or from about 100 CE mg/g to about 500 CE mg/g of polyphenols. 
     
     
         2 . The method of  claim 1 , wherein the composition comprises from about 0.05 wt % to about 10 wt % of the extract. 
     
     
         3 . The method of  claim 2 , wherein the composition comprises from about 0.05 wt % to about 5 wt % of the extract. 
     
     
         4 . The method of  claim 1 , wherein the skin condition is selected from the group consisting of atopic dermatitis, eczema, psoriasis, dry skin, oily skin, and pruritic skin. 
     
     
         5 . (canceled) 
     
     
         6 . The method of  claim 1 , wherein the skin condition is selected from the group consisting of wrinkles, fine lines, dark spots, age spots, mottled pigmentation, skin pigmentation, melasma, darkened skin, skin elasticity, dark circles under the eyes and changes associated with skin aging. 
     
     
         7 . (canceled) 
     
     
         8 . (canceled) 
     
     
         9 . The method of  claim 1 , wherein the skin condition is acne. 
     
     
         10 . The method of  claim 1 , wherein the skin condition is wound healing. 
     
     
         11 . The method of  claim 1 , wherein the skin condition is hair loss. 
     
     
         12 . The method of  claim 1 , wherein the prevention, improvement or treatment of the skin condition provides skin moisturisation, skin exfoliation, skin lightening or colour reduction, skin pigmentation reduction, skin redness reduction, skin flushing reduction, inflammation reduction, fine line reduction, wrinkle reduction, wrinkle depth reduction, skin dryness reduction, skin roughness reduction, enhanced skin radiance, enhanced skin tone, enhanced skin clarity, enhanced skin firmness, enhanced skin tightness, enhanced skin elasticity, and/or enhanced overall skin appearance. 
     
     
         13 . (canceled) 
     
     
         14 . (canceled) 
     
     
         15 . (canceled) 
     
     
         16 . (canceled) 
     
     
         17 . The method of  claim 10 , wherein the improvement or treatment of wound healing provides decreased formation of scar tissue, improved healing time, improved appearance of the healed skin, protection of the healing skin tissue from oxidative damage, and/or prevention or treatment of the wound from infection. 
     
     
         18 . The method of  claim 1 , wherein administration is: i) topical; or ii) by injection. 
     
     
         19 . (canceled) 
     
     
         20 . The method of  claim 1 , wherein the composition is administered:
 i) once daily; or   ii) twice daily.   
     
     
         21 . (canceled) 
     
     
         22 . (canceled) 
     
     
         23 . (canceled) 
     
     
         24 . The method of  claim 18 , wherein the composition is in the form of a cream, serum or gel. 
     
     
         25 . The method of  claim 1 , wherein the extract comprises from about 15 CE g/L to about 40 CE g/L of polyphenols or about 150 CE mg/g to about 400 CE mg/g of polyphenols. 
     
     
         26 . The method of  claim 25 , wherein the extract comprises from about 20 CE g/L to about 30 CE g/L of polyphenols or from about 200 CE mg/g to about 300 CE mg/g of polyphenols. 
     
     
         27 . The method of  claim 1 , wherein the extract is derived from a sugar cane derived product selected from the group consisting of molasses, massecuite, bagasse, first expressed juice, mill mud, clarified sugar juice, clarified syrup, treacle, golden syrup, field trash, cane strippings, dunder and combinations thereof. 
     
     
         28 . (canceled) 
     
     
         29 . The method of  claim 1 , wherein the composition comprises lactic acid and/or glycolic acid. 
     
     
         30 . An extract derived from sugar cane for preventing, improving or treating a skin condition, the extract comprising from about 10 catechin equivalent (CE) g/L to about 50 CE g/L of polyphenols or from about 100 CE mg/g to about 500 CE mg/g of polyphenols, and wherein the medicament is formulated to be administered topically or by injection and comprises from about 0.05 wt % to about 50 wt % of the extract derived from sugar cane. 
     
     
         31 . A composition comprising from about 0.05 wt % to about 50 wt % of an extract derived from sugar cane for use in preventing, improving or treating a skin condition in a subject, the extract comprising from about 10 catechin equivalent (CE) g/L to about 50 CE g/L of polyphenols or from about 100 CE mg/g to about 500 CE mg/g of polyphenols, and wherein the use is topical or by injection.