Sterile liquid composition for filling wrinkles

Abstract

The subject matter of the present invention is a sterile liquid composition dedicated to administration into or through the skin and/or the lips, wherein said composition comprises, in a physiologically acceptable medium, at least one photo-crosslinkable compound, wherein said compound comprises at least one activated photo-dimerizable group having at least one activated double bond and selected from photo-dimerizable groups carrying a stilbazolium function of formula (Ia) or (Ib) and wherein the photo-dimerizable groups carry a styrylazolium function of formula (II), the photo-dimerizable group(s) being carried by a partially or totally hydrolysed poly(vinyl acetate) polymer, a polysaccharide or a polyvinyl alcohol

1 . A sterile liquid composition dedicated to administration into or through the skin and/or the lips, said composition comprising, in a physiologically acceptable medium, at least one photo-crosslinkable compound, wherein said compound comprises at least one activated photo-dimerizable group having at least one activated double bond and selected from:
 a) photo-dimerizable groups bearing a stilbazolium function of formula (Ia) or (Ib):   
       
         
           
           
               
               
           
         
       
       where:
 R represents a hydrogen atom or a C 1 -C 4  alkyl or C 1 -C 4  hydroxyalkyl group, 
 R′ represents a hydrogen atom or a C 1 -C 4  alkyl group, and 
 X −  denotes an ion selected from chloride, bromide, iodide, perchlorate, tetrafluoroborate, methyl sulfate, phosphate, sulfate, methanesulfonate and p-toluenesulfonate ions, 
 
       
         
           
           
               
               
           
         
       
       where:
 R″ denotes a divalent alkylene radical having from 2 to 8 carbon atoms, 
 R′ represents a hydrogen atom or a C 1 -C 4  alkyl group, and 
 X −  has the same meaning as that described for formula (Ia) above, 
 b) photo-dimerizable groups bearing a styrylazolium function of formula (II): 
 
       
         
           
           
               
               
           
         
       
       wherein:
 R 1  denotes a hydrogen atom or a C 1 -C 4  alkyl or C 1 -C 4  hydroxyalkyl group, 
 A denotes a sulfur atom, an oxygen atom or a group NR′ or C(R′) 2 , R′, R′ representing a hydrogen atom or a C 1 -C 4  alkyl group, and 
 X −  has the same meaning as that described for formula (Ia) above, the photo-dimerizable group(s) being borne by a partially or totally hydrolyzed poly(vinyl acetate) polymer, a polysaccharide or a polyvinyl alcohol. 
 
     
     
         2 . The composition as claimed in  claim 1 , characterized in that the photo-dimerizable group is a photo-dimerizable group bearing a stilbazolium function of formula (Ia): 
       
         
           
           
               
               
           
         
       
       where:
 R represents a hydrogen atom or a C 1 -C 4  alkyl or C 1 -C 4  hydroxyalkyl group, 
 R′ represents a hydrogen atom or a C 1 -C 4  alkyl group, and 
 X −  denotes an ion selected from chloride, bromide, iodide, perchlorate, tetrafluoroborate, methyl sulfate, phosphate, sulfate, methanesulfonate and p-toluenesulfonate ions. 
 
     
     
         3 . The composition as claimed in  claim 1 , characterized in that it is devoid of photoinitiator and/or of chemical initiator. 
     
     
         4 . The composition as claimed in  claim 1 , wherein the photo-dimerizable groups are borne by a polyvinyl alcohol. 
     
     
         5 . The composition as claimed in  claim 1 , wherein the photo-crosslinkable compound is a polyvinyl alcohol partly functionalized with one or more hydroxyl function(s) and one or more function(s) of formula (III): 
       
         
           
           
               
               
           
         
       
     
     
         6 . The composition as claimed in  claim 1 , characterized in that the degree of functionalization with photo-dimerizable units is at least 0.1%, or even at least 0.5%, or even at least 2%. 
     
     
         7 . The composition as claimed in  claim 1 , wherein the photo-crosslinkable compound represents at least 2%, or even at least 5%, or even 10% of the total volume of the composition. 
     
     
         8 . The composition as claimed in  claim 1 , also comprising at least one optical tracer or one fluorescent compound. 
     
     
         9 . The composition as claimed in  claim 1 , also comprising at least one additional active agent, in particular an antiwrinkle active agent. 
     
     
         10 . A cosmetic process for treating the skin and/or the lips, comprising the following steps:
 i. administration into or through the skin and/or the lips of a composition as claimed in  claim 1 , and   ii. illumination of the skin and/or the lips treated according to step i. in order to crosslink the composition.   
     
     
         11 . The cosmetic process for treating the skin and/or the lips as claimed in  claim 10 , wherein the illumination is a light source with radiation in the visible range and/or radiation in the UV range and preferably radiation in the visible range. 
     
     
         12 . A system for treating the skin and/or the lips, comprising:
 a packaging containing at least one dose of a composition as claimed in  claim 1 , and   a device for injection into or through the skin and/or the lips or a device for microperforation of the skin and/or of the lips, dedicated to the administration of said dose.   
     
     
         13 . The treatment system as claimed in  claim 12 , also comprising an imager. 
     
     
         14 . The treatment system as claimed in  claim 12 , also comprising an injection device suitable for intraepidermal and/or intradermal and/or subcutaneous injection. 
     
     
         15 . The treatment system as claimed in  claim 12 , wherein the injection device is selected from a syringe, a set of microsyringes, a hydraulic laser device or a scalpel. 
     
     
         16 . The treatment system as claimed in  claim 12 , wherein the injection device is suitable for the mesotherapy technique. 
     
     
         17 . An assembly for treating esthetic imperfections of the skin and/or of the lips, comprising:
 i. a treatment system as claimed in  claim 12 , and   ii. a lighting system capable of photo-crosslinking the compound.   
     
     
         18 . The treatment assembly as claimed in  claim 17 , also comprising at least:
 i. one system for analyzing at least one area to be treated,   ii. one source of other means of activation selected from a source of heat, of microwaves, of sound waves, a light source which does not facilitate crosslinking of the compound(s),   iii. one system for applying a stress before or during the illumination,   iv. one device for eliminating the unreacted compounds.