US2020197488A1PendingUtilityA1

Compositions and methods for treating hair loss

71
Assignee: UNIV PENNSYLVANIAPriority: Mar 29, 2005Filed: Jan 28, 2019Published: Jun 25, 2020
Est. expiryMar 29, 2025(expired)· nominal 20-yr term from priority
Inventors:George CotsarelisOh-Sang Kwon
A61K 38/18A61P 17/14A61K 38/1825A61K 45/06A61Q 7/00A61K 38/20A61K 8/64A61M 37/00A61N 2005/1098A61P 35/00A61M 2037/0007A61N 5/10A61P 43/00A61P 17/00Y10S514/88
71
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Claims

Abstract

The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (HF), and increasing the size of existing HF. The methods comprise epidermal disruption or administration of wnt, a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of treating hair loss in a subject, the method comprising: administering an effective amount of a sonic hedgehog (Shh) agonist to said subject, thereby treating said hair loss in said subject. 
     
     
         2 . The method of  claim 1 , wherein the method comprising the steps of: wounding a region of said hair loss in said subject; and administering said effective amount of said sonic hedgehog (Shh) agonist to the wounded area of said subject. 
     
     
         3 . The method of  claim 2 , wherein the step wounding is performed by disrupting a dermis or an epidermis in the region of said hair loss in said subject. 
     
     
         4 . The method of  claim 1 , wherein said sonic hedgehog (Shh) agonist is Hh-Ag. 
     
     
         5 . The method of  claim 1 , wherein the subject is a human. 
     
     
         6 . The method of  claim 1 , wherein the subject has hair loss. 
     
     
         7 . The method of  claim 1 , wherein said hair loss is due to androgenetic alopecia (AGA). 
     
     
         8 . The method of  claim 7 , wherein the AGA is male pattern baldness or female pattern baldness. 
     
     
         9 . The method of  claim 1 , wherein said hair loss is due to skin injury. 
     
     
         10 . The method of  claim 1 , wherein said hair loss is in the scalp or eyebrow of said subject. 
     
     
         11 . The method of  claim 7 , wherein said AGA is in the scalp or eyebrow. 
     
     
         12 . The method of  claim 1 , wherein said hair loss is in scarred skin tissue of said subject. 
     
     
         13 . The method of  claim 3 , wherein said disrupting is performed by exposing the region of said hair loss to a mechanical or chemical stimulus. 
     
     
         14 . The method of  claim 3 , wherein said disrupting is performed by exposing the region of said hair loss to radiation. 
     
     
         15 . A method of increasing the number of hair follicles in a subject, the method comprising: administering an effective amount of a sonic hedgehog (Shh) agonist to said subject, thereby treating increasing the number of hair follicles in said subject. 
     
     
         16 . The method of  claim 15 , wherein the method comprising the steps of: wounding a region of said hair loss in said subject; and administering said effective amount of said sonic hedgehog (Shh) agonist to the wounded area of said subject. 
     
     
         17 . The method of  claim 16 , wherein the step wounding is performed by disrupting a dermis or an epidermis in the region of said hair loss in said subject. 
     
     
         18 . The method of  claim 15 , wherein said sonic hedgehog (Shh) agonist is Hh-Ag. 
     
     
         19 . The method of  claim 15 , wherein the subject is a human. 
     
     
         20 . The method of  claim 15 , wherein the subject has hair loss. 
     
     
         21 . The method of  claim 20 , wherein said hair loss is due to androgenetic alopecia (AGA). 
     
     
         22 . The method of  claim 21 , wherein the AGA is male pattern baldness or female pattern baldness. 
     
     
         23 . The method of  claim 20 , wherein said hair loss is due to skin injury. 
     
     
         24 . The method of  claim 20 , wherein said hair loss is in the scalp or eyebrow of said subject. 
     
     
         25 . The method of  claim 21 , wherein said AGA is in the scalp or eyebrow. 
     
     
         26 . The method of  claim 20 , wherein said hair loss is in scarred skin tissue of said subject. 
     
     
         27 . The method of  claim 17 , wherein said disrupting is performed by exposing the region of said hair loss to a mechanical or chemical stimulus. 
     
     
         28 . The method of  claim 17 , wherein said disrupting is performed by exposing the region of said hair loss to radiation.

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