Removable film forming gel compositions and methods for their application

Abstract

Film forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film forming polymer, a tackifier, and a volatile solvent. The film forming gels can also include antiseptics, cationic polymer coagulants, fillers, and other additives. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing.

What is claimed is: 
     
         1 . A bandage formed by drying a gel composition, the gel composition comprising:
 (a) about 10-30 wt. % silicone containing, film forming polymer, wherein the film forming polymer is a polydiorganosiloxane polyoxamide;   (b) about 2-20 wt. % tackifier;   (c) about 60-80 wt. % volatile solvent; and   (d) about 0.5-20 wt. % crosslinked guanidinyl-containing polymer particles having primary or secondary amino groups,   each based on the total weight of the gel composition,   wherein the viscosity of the gel composition is between about 70,000 cps and about 800,000 cps; and   wherein the gel composition forms a bandage and/or tissue protector that can be removed by peeling.   
     
     
         2 . The bandage of  claim 1 , having an upright MVTR of at least 300 g/m 2 /24 hours. 
     
     
         3 . The bandage of  claim 1 , having a Skin Adhesion of at least 50 g/inch and no greater than 900 g/inch. 
     
     
         4 . The bandage of  claim 1 , having an elongation of between about 100% and about 1400%. 
     
     
         5 . The bandage of  claim 1 , having an ultimate tensile strength of at least 0.3 MPa. 
     
     
         6 . The bandage of  claim 1 , having a thickness of between about 2 mil and about 20 mil. 
     
     
         7 . The bandage of  claim 1 , having a 180 degree peel adhesion from human skin of between about 25 g/in and about 1000 g/in. 
     
     
         8 . A film useful as a conformable bandage, wherein the film exhibits an upright MVTR of at least 300 g/m 2 /24 hours, a Skin Adhesion of at least 50 g/inch and no greater than 900 g/inch, an elongation of at least 100%, and an ultimate tensile strength of at least 0.3 MPa, wherein at least a portion of the film has a thickness of at least 2 mils and no greater than 20 mils, and wherein the film is self-supporting and comprises a crosslinked, guanidinyl-containing polymer. 
     
     
         9 . The film of the  claim 8 , wherein the film comprises:
 (a) 50-75 wt. % film forming polymer;   (b) 15-30 wt. % tackifier;   (c) 0.1-30 wt. % filler; and   (e) 5-35 wt. % guanidinyl-containing polymer, based on the weight of the film.   
     
     
         10 . The film of  claim 9 , wherein the film forming polymer is a silicone containing polymer selected from the group consisting of polydiorganosiloxane polyurea, polydiorganosiloxane polyamine, polysiloxane carbonate, polydiorganosiloxane polyamide, and combinations thereof, wherein the polydiorganosiloxane polyamide is a polydiorganosiloxane polyoxamide. 
     
     
         11 . The film of  claim 8 , wherein the film consists of a single layer. 
     
     
         12 . The film of  claim 8 , wherein the guanidinyl-containing polymer is aminopolymer functionalized with one or more guanidinyl groups. 
     
     
         13 . The film of  claim 12 , wherein the guanidinyl-containing polymer is guanidinylated polyethylene imine. 
     
     
         14 . A film forming gel composition for use as a conformable film bandage, the composition comprising:
 a silicone containing, film forming polymer;   a tackifier comprising a silicate tackifying resin;   a coagulant comprising a cationic polymer distinct from the film forming polymer; and   a volatile solvent,   wherein a film cast from the composition is self-supporting on a biological substrate and can be peeled off the substrate without substantially compromising the integrity of the film such that at least a portion of the film is removable in a single continuous layer.   
     
     
         15 . The film forming gel composition of  claim 14 , comprising a) 10-30 wt. % film forming polymer, (b) 3-20 wt. % tackifier, (c) 60-80 wt. % volatile solvent, (d) 0.5-20 wt. % cationic polymer, based on the total weight of the gel composition. 
     
     
         16 . The film forming gel composition of  claim 14 , wherein the film forming polymer is selected from the group consisting of polydiorganosiloxane polyurea, polydiorganosiloxane polyamine, polysiloxane carbonate, polydiorganosiloxane polyamide, and combinations thereof, wherein the polydiorganosiloxane polyamide is a polydiorganosiloxane polyoxamide. 
     
     
         17 . The film forming gel composition of  claim 14 , wherein the coagulant comprises a crosslinked, guanidinyl-containing aminopolymer. 
     
     
         18 . The film forming gel composition of  claim 14 , wherein the Brookfield viscosity of the composition is at least 100,000 cps and no greater than 500,000 cps.