Treatment of short bowel syndrome patients with colon-in-continuity

Abstract

Intestinal absorption is enhanced in short bowel syndrome patients presenting with colon-in-continuity by treatment with a GLP-2 receptor agonist, such as teduglutide.

1 . A method of treating an adult human patient having short bowel syndrome with colon-in-continuity and remnant small intestine ranging from about 25 cm to about 200 cm and who receives an amount of parenteral nutrition each week, said method comprising administering [Gly2]hGLP-2 to said patient using a dosing regimen effective to reduce or eliminate said weekly amount of parenteral nutrition received by said patient. 
     
     
         2 . The method as defined in  claim 1 , wherein the [Gly2]hGLP-2 is administered at a daily dose of from 5 to 500 μg/kg. 
     
     
         3 . The method as defined in  claim 2 , wherein the [Gly2]hGLP-2 is administered at a daily dose of from 30 to 150 μg/kg. 
     
     
         4 . The method as defined in  claim 1 , wherein the [Gly2]hGLP-2 is administered by subcutaneous injection. 
     
     
         5 . The method as defined in  claim 4 , wherein the subcutaneous injection is into the abdomen, thigh, or arm. 
     
     
         6 . The method as defined in  claim 1 , wherein said patient has a length of small intestine ranging from about 50 to 150 cm. 
     
     
         7 . A method of treating an adult human patient having short bowel syndrome with colon-in-continuity and remnant small intestine ranging from about 25 cm to about 200 cm and who receives an amount of parenteral nutrition each week, said method comprising administering [Gly2]hGLP-2 to said patient using a dosing regimen effective to increase wet weight absorption compared to a baseline wet weight absorption by said patient. 
     
     
         8 . The method as defined in  claim 7 , wherein the [Gly2]hGLP-2 is administered at a daily dose of from 5 to 500 μg/kg. 
     
     
         9 . The method as defined in  claim 8 , wherein the [Gly2]hGLP-2 is administered at a daily dose of from 30 to 150 μg/kg. 
     
     
         10 . The method as defined in  claim 7 , wherein the [Gly2]hGLP-2 is administered by subcutaneous injection. 
     
     
         11 . The method as defined in  claim 10 , wherein the subcutaneous injection is into the abdomen, thigh, or arm. 
     
     
         12 . The method as defined in  claim 7 , wherein said patient has a length of small intestine ranging from about 50 to 150 cm. 
     
     
         13 . The method as defined in  claim 7 , wherein the [Gly2]hGLP-2 is administered at a daily dose of from 5 to 500 μg/kg. 
     
     
         14 . The method as defined in  claim 8 , wherein the [Gly2]hGLP-2 is administered at a daily dose of from 30 to 150 μg/kg. 
     
     
         15 . The method as defined in  claim 7 , wherein the [Gly2]hGLP-2 is administered by subcutaneous injection. 
     
     
         16 . The method as defined in  claim 10 , wherein the subcutaneous injection is into the abdomen, thigh, or arm. 
     
     
         17 . The method as defined in  claim 7 , wherein said patient has a length of small intestine ranging from about 50 to 150 cm. 
     
     
         18 . The method as defined in  claim 1 , wherein said regimen comprises administration of the [Gly2]hGLP-2 over a period of at least 21 days. 
     
     
         19 . The method as defined in  claim 7 , wherein said regimen comprises administration of the [Gly2]hGLP-2 over a period of at least 21 days. 
     
     
         20 . The method as defined in  claim 1 , wherein the parenteral nutrition is reduced by volume or frequency of administration.