Oral Care Compositions and Methods of Use

Abstract

This invention relates to oral care compositions comprising a basic amino acid in free or salt from (e.g., free form arginine); zinc oxide and zinc citrate; and a fluoride source comprising stannous fluoride.

1 . An oral care composition comprising:
 a. a basic amino acid in free or salt form;   b. zinc oxide and zinc citrate;   c. a fluoride source comprising stannous fluoride.   
     
     
         2 . The oral care composition of  claim 1 , wherein the basic amino acid is arginine and wherein the arginine has the L- configuration. 
     
     
         3 . The oral care composition of  claim 1 , wherein the amino acid is arginine in an amount corresponding to 0.1 wt. % to 15 wt. %, based on the total weight of the composition, the weight of the basic amino acid being calculated as free form. 
     
     
         4 . The oral care composition of  claim 1  wherein the amino acid is arginine in an amount corresponding to 0.1 wt. % to 5 wt. %, based on the total weight of the composition, the weight of the basic amino acid being calculated as free form. 
     
     
         5 . The oral care composition of  claim 1  wherein the amino acid is arginine in an amount of about 1.5 wt. %, based on the total weight of the composition, the weight of the basic amino acid being calculated as free form. 
     
     
         6 . The oral care composition of  claim 1  wherein the amino acid is arginine in free form. 
     
     
         7 . The oral care composition of  claim 1  wherein the amino acid is arginine partially or wholly in salt form. 
     
     
         8 . The oral care composition of  claim 1  wherein the ratio of the amount of zinc oxide (by wt. %) to zinc citrate (by wt. %) is 2:1, 2.5:1, 3:1, 3.5:1 or 4:1, wherein the ratio is by weight of the overall composition. 
     
     
         9 . The oral care composition of  claim 8 , wherein the ratio of the amount of zinc oxide (by wt. %) to zinc citrate (by wt. %) is 2:1. 
     
     
         10 . The oral care composition of  claim 1 , wherein the zinc citrate is in an amount of from 0.25 to 1.0 wt. % and zinc oxide may be present in an amount of from 0.75 to 1.25 wt. % based on the total weight of the composition. 
     
     
         11 . The oral care composition of  claim 10 , wherein the zinc citrate is in an amount of about 0.5 wt. % and zinc oxide is present in an amount of about 1.0 wt. % based on the total weight of the composition. 
     
     
         12 . The oral care composition of  claim 1 , wherein the fluoride source further comprises at least one member selected from the group of: sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, titanium fluoride, hexafluorosulfate, and combinations thereof. 
     
     
         13 . The oral care composition of  claim 1 , wherein the stannous fluoride is present in an amount from 0.1 wt. % to 2 wt. % based on the total weight of the composition. 
     
     
         14 . The oral care composition of  claim 1 , wherein the stannous fluoride is a soluble fluoride salt which provides soluble fluoride in amount of 50 to 25,000 ppm fluoride. 
     
     
         15 . The composition of  claim 14 , wherein stannous fluoride provides soluble fluoride in an amount of about 750 -7000 ppm. 
     
     
         16 . The composition of  claim 14 , wherein sodium fluoride provides soluble fluoride in an amount of about 1000-5500 ppm. 
     
     
         17 . The composition of  claim 14 , wherein sodium fluoride provides soluble fluoride in an amount of about 5000 ppm. 
     
     
         18 . The oral care composition of  claim 1  comprising:
 a. about 1.0% zinc oxide 
 b. about 0.5% zinc citrate 
 c. about 1.5% L-arginine 
 d. about 750-7000 ppm fluoride; and 
 e. about 5% small particle silica, based on the total weight of the composition. 
 
     
     
         19 . The oral care composition of  claim 1  comprising:
 a. about 1.0% zinc oxide 
 b. about 0.5% zinc citrate 
 c. about 750-7000 ppm stannous fluoride; and 
 d. about 39.2% glycerin based on the total weight of the composition. 
 
     
     
         20 . The oral care composition of  claim 1 , wherein the oral composition may be any of the following oral compositions selected from the group consisting of: a toothpaste or a dentifrice, a mouthwash or a mouth rinse, a topical oral gel, and a denture cleanser. 
     
     
         21 . The oral care composition of  claim 1 , wherein the composition is obtained or obtainable by combining the ingredients as set forth in any of the preceding compositions.