US2020129522A1PendingUtilityA1
Compounds and methods for modulating frataxin expression
Assignee: WISCONSIN ALUMNI RES FOUNDPriority: Mar 30, 2016Filed: Dec 11, 2019Published: Apr 30, 2020
Est. expiryMar 30, 2036(~9.7 yrs left)· nominal 20-yr term from priority
A61K 47/545A61K 47/55C08L 77/00A61P 25/28A61K 31/785C07D 495/14A61K 31/5517A61K 31/4164C08G 69/08A61K 31/795C07D 513/12
68
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Claims
Abstract
The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and —B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.
Claims
exact text as granted — not AI-modifiedWe claim:
1 . An agent having a formula A-L-B, wherein -L- is a linker; A- is a bromodomain inhibitor; and —B is a polyamide.Join the waitlist — get patent alerts
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