Compositions using cross-linked hyaluronic acid for topical cosmetic and therapeutic applications

Abstract

Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.

1 - 20 . (canceled) 
     
     
         21 . A topical composition comprising: hylan B and an active ingredient, the active ingredient not including water or buffer, wherein hylan B in a non-equilibrium form is loaded by swelling with the active ingredient, thereby the active ingredient becomes entrapped within the hylan B gel matrix. 
     
     
         22 . The composition according to  claim 21 , wherein the active ingredient is a hydrophilic organic ingredient. 
     
     
         23 . The composition according to  claim 22 , wherein the hydrophilic organic ingredient is an α-, β-, γ-, or δ-hydroxy acid, an α-amino acid, a β-amino acid, a γ-amino acid, δ-amino acid, a glycerin, a vitamin, a vitamin derivative, a sugar, an essential oil, a water-soluble oil, a fragrance, a natural polymer, a synthetic polymer, a cross-linked natural polymer, a cross linked synthetic polymer, a peptide, a protein, a polysaccharide or a nucleic acid. 
     
     
         24 . The composition according to  claim 23 , wherein the hydrophilic organic ingredient is an α-hydroxy acid. 
     
     
         25 . The composition according to  claim 21 , wherein the active ingredient is a hydrophobic organic ingredient. 
     
     
         26 . The composition according to  claim 25 , wherein the hydrophobic organic ingredient is a petrolatum, a fatty acid, a fatty alcohol, an oil, a lipid or a silicone. 
     
     
         27 . The composition according to  claim 21 , wherein the active ingredient is an inorganic ingredient. 
     
     
         28 . The composition according to  claim 27 , wherein the inorganic ingredient is titanium dioxide, silica, calcium chloride, kaolin, talc or tantalum. 
     
     
         29 . The composition according to  claim 21 , wherein the active ingredient is an anti-inflammatory agent, an antiseptic agent, an anti-infective agent, a mucous membrane agent, a cleansing agent, a preservative, an astringent, an antihistamine, an analgesic, an anesthetic, an acne medication, an antifungal agent, an anti-pruritic agent, a hormone, a growth factor, a moisturizing agent, a sunscreen, a hyperpigmentation agent, an antioxidant or a nutritional agent. 
     
     
         30 . The composition according to  claim 29 , wherein the nutritional agent is a vitamin. 
     
     
         31 . The composition according to  claim 29 , wherein the sunscreen is Parsol MCX. 
     
     
         32 . The composition according to  claim 29 , wherein the active ingredient is an anti-inflammatory agent in combination with an anti-infective agent. 
     
     
         33 . The composition according to  claim 29 , wherein the anti-inflammatory agent is a steroid agent. 
     
     
         34 . The composition according to  claim 33 , wherein the steroid agent is hydrocortisone, hydrocortisone acetate or prednisone. 
     
     
         35 . The composition according to  claim 32 , wherein the anti-infective agent is an antibiotic. 
     
     
         36 . The composition according to  claim 35 , wherein the antibiotic is bacitracin. 
     
     
         37 . The composition according to  claim 29 , wherein the antiseptic agent is povidone iodine. 
     
     
         38 . The composition of  claim 21 , wherein the active ingredient is hyaluronic acid (HA). 
     
     
         39 . The composition of  claim 38 , wherein the composition is a gel slurry. 
     
     
         40 . The composition according to  claim 21 , wherein the topical composition comprises loaded hylan B in a non-equilibrium form. 
     
     
         41 . The composition according to  claim 21 , wherein the topical composition comprises loaded hylan B in an equilibrium form.