Composition comprising aqueous medium with reduced size water clusters to improve bioavailability of the aqueous medium and methods for making and using the compositions

Abstract

The invention relates to products by processes, product compositions, product formulations and product uses that are all related to reduced ultrapure water cluster sizes in an aqueous composition containing a non-H2O substance in the reduced size water clusters in order to improve bioavailability of the aqueous composition. The invention processes use higher flow rate of the blended aqueous composition from a jet openings of a nozzle inside the hollow cylinder to reduce sizes of the ultrapure water clusters in the blended aqueous composition of the non-H2O substance to less than 300 nanometers.

1 - 20 . (canceled) 
     
     
         21 . A method for producing reduced sized water clusters comprising:
 pumping a first solution of ultrapure water comprising water clusters having a first size through a transfer pipe and a nozzle into a hollow cylinder,
 wherein the nozzle is located at the proximal end of the hollow cylinder and comprises: 
 (i) an intake hole in a proximal face of the nozzle connected to the transfer pipe; and 
 (ii) one or more jet openings in a distal face of the nozzle that open into a chamber defined by the hollow cylinder; 
 wherein the ultrapure water passing through the one or more jet openings creates vortex of ultrapure water in contact in an inner surface of the chamber to produce a second solution of ultrapure water; and 
 wherein the second solution of ultrapure water comprises water clusters having a second size that is less than the size of the water clusters in the first solution having a first size. 
   
     
     
         22 . The method of  claim 21 , wherein the median diameter of the water clusters in the second solution is between about 2 to about 400 nanometers. 
     
     
         23 . The method of  claim 21 , wherein the median diameter of the water clusters in the second solution is between about 2 to about 50 nanometers. 
     
     
         24 . The method of  claim 21 , wherein the median diameter of the water clusters in the second solution is about 2.5 nanometers. 
     
     
         25 . The method of  claim 21 , wherein the water clusters in the second solution comprise about 150 to about 300 water molecules. 
     
     
         26 . The method of  claim 21 , wherein the first solution is pumped through the transfer pipe at a flow rate between about 10 to about 25 gallons per minute. 
     
     
         27 . The method of  claim 26 , wherein the flow rate is between about 12 to about 18 gallons per minute. 
     
     
         28 . The method of  claim 26 , wherein the width of the chamber is between about 1 to about 20 inches, the length of the chamber is between about 1 to about 80 inches, and the flow rate is equal to or greater than about 14 gallons per minute. 
     
     
         29 . The method of  claim 26 , wherein the width of the chamber is about 4 inches, the length of the chamber is about 18 inches, and the flow rate is about 14 gallons per minute. 
     
     
         30 . The method of  claim 21 , wherein the first solution is pumped through the transfer pipe under a pressure of between about 10 to about 70 pounds per square inch. 
     
     
         31 . The method of  claim 21 , wherein the first solution is pumped through the transfer pipe under a pressure of between about 25 to about 40 pounds per square. 
     
     
         32 . The method of  claim 21 , wherein the resistivity of the first solution of ultrapure water is between about 17 to about 18.2 meg-ohm cm. 
     
     
         33 . The method of  claim 21 , wherein the first solution has a pH of about 6 to about 7. 
     
     
         34 . The method of  claim 21 , wherein the first solution has an oxidative reduction potential of about 88 to about 92 my. 
     
     
         35 . The method of  claim 21 , wherein the pH of he second solution is about 4 to about 6. 
     
     
         36 . The method of  claim 21 , wherein the second solution has an oxidative reduction potential of about 140 to about 160 my. 
     
     
         37 . The method of  claim 21 , further comprising selecting a first solution of ultrapure water comprising water clusters having a first size. 
     
     
         38 . The method of  claim 21 , further comprising collecting the second solution of ultrapure water comprising water clusters having a second size. 
     
     
         39 . The method of  claim 21 , wherein the first solution of ultrapure water is prepared by carbon filtration, slow sand filtration, reverse osmosis, electro-deionization treatment, ultraviolet light exposure, or a combination thereof. 
     
     
         40 . The method of  claim 21 , wherein the one or more jet openings redirect the ultrapure water by an average of between about 0 to about 90 degrees relative to a long axis of the transfer pipe. 
     
     
         41 . The method of  claim 21 , wherein the first solution further comprises one or more solutes. 
     
     
         42 . The method of  claim 39 , wherein the one or more solutes are encapsulated within the water clusters in the second solution. 
     
     
         43 . The method of  claim 41 , wherein the one or more solutes comprise an ion of an ionizable salt. 
     
     
         44 . The method of  claim 43 , wherein the ion is selected from the group consisting of selected from aluminum ion, ammonium ion, antimony ion, arsenic ion, barium ion, beryllium ion, bismuth ion, boron ion, bromide ion, cadmium ion, calcium ion, cerium ion, cesium cation, chloride ion, chromium ion, cobalt ion, copper ion, dysprosium ion, erbium ion, europium ion, fluoride ion, gadolinium ion, gallium ion, germanium ion, gold ion, hafnium ion, holmium ion, indium ion, iodine ion, iridium ion, iron ion, lanthanum ion, lead ion, lithium ion, lutetium ion, magnesium ion, manganese ion, mercury ion, molybdenum ion, neodymium ion, nickel ion, niobium ion, osmium ion, palladium ion, phosphorus ion, platinum ion, potassium ion, praseodymium ion, rhenium ion, rhodium ion, rubidium ion, ruthenium ion, samarium ion, scandium ion, selenium ion, silicon ion, silver ion, sodium ion, strontium ion, sulfate ion, tantalum ion, tellurium ion, terbium ion, thallium ion, thorium ion, thulium ion, tin ion, titanium ion, tungsten ion, vanadium ion, ytterbium ion, yttrium ion, zinc ion, and zirconium ion. 
     
     
         45 . The method of  claim 41 , wherein the one or more solutes are comprised of:
 (i) potassium chloride, vitamin B6, ferric chloride, magnesium sulfate, sodium chloride, ionic Trace Minerals, kelp, taurine, alfalfa; and sodium borate; or   (ii) capsaicin, resveratrol, quercetin, vitamin D3, and  panax ginseng ; or   (iii) synapta, magnesium chloride, concentrated trace minerals, and sodium benzoate;   or a combination thereof.   
     
     
         46 . A hydration product prepared according to the method of  claim 39 . 
     
     
         47 . A fertilizer product prepared according to the method of  claim 39 . 
     
     
         48 . A solution for administration to a subject in need thereof comprising one or more solutes encapsulated within water clusters, wherein the solution is prepared according to the method of  claim 39 . 
     
     
         49 . The solution of  claim 47 , wherein the one of more solutes comprise one or more solutes selected from an organic chemical, an inorganic chemical, a fat, a peptide, a sugar, a synthetic polymer, polyethylene, nylon, polypropylene, a wax, an oil, a colloid, an oligosaccharide, a polysaccharide, a protein, a fatty acid, a DNA nucleotide, a polynucleotide, an RNA polynucleotide, a pharmaceutical drug, a surfactant, a hydrogel, a hydrophilic substance, a catalyst, a free radical scavenger, an ion chelator, avidin, steptavidin, a paramagnetic substance, a magnetic field sensitive substance, a radioactive substance, a radiocontrast agent, an ultrasound contrast agent, a cerium oxide, an oderant, a perfume, a pheromone, a hormone, a cytokine, an interleukin, blebbistatin, a blebbistatin derivative, PNC-27, Keytruda®, an antibody, a biological cell organelle, an intact biological, a fluorescent compound, a polymerase, a P450 enzyme, a PCR enzyme, a catalyst, or any combination thereof. 
     
     
         50 . A process for encapsulating a solute in a water cluster, the process comprising:
 preparing a first solution of ultrapure water comprising a solute;   pumping the first solution through a transfer pipe and a nozzle to a hollow cylinder at a flow rate;
 wherein the nozzle is located at the proximal end of the hollow cylinder and comprises: 
 (i) an intake hole in a proximal face of the nozzle connected to the transfer pipe; and 
   (ii) one or more jet openings in a distal face of the nozzle that are in contact with a chamber defined by the hollow cylinder;   wherein the ultrapure water passing through the jet openings at the flow rate creates a vortex of ultrapure water in contact in an inner surface of the chamber; and   collecting a second solution of ultrapure water comprising the solute encapsulated within a water cluster after passage through the nozzle and chamber.   
     
     
         51 . The process of  claim 50 , wherein the one or more solutes comprise an ion of an ionizable salt. 
     
     
         52 . The process of  claim 51 , wherein the ionizable salt is selected from aluminum ion, ammonium ion, antimony ion, arsenic ion; barium ion, beryllium ion, bismuth ion, boron ion, bromide ion, cadmium ion, calcium ion, cerium ion, cesium cation, chloride ion; chromium ion, cobalt ion, copper ion, dysprosium ion, erbium ion, europium ion, fluoride ion, gadolinium ion, gallium ion; germanium ion, gold ion, hafnium ion, holmium ion, indium ion, iodine ion, iridium ion, iron ion, lanthanum ion, lead ion, lithium ion, lutetium ion, magnesium ion, manganese ion, mercury ion, molybdenum ion, neodymium ion; nickel ion, niobium ion, osmium ion, palladium ion, phosphorus ion, platinum ion, potassium ion, praseodymium ion, rhenium ion, rhodium ion, rubidium ion, ruthenium ion, samarium ion, scandium ion, selenium ion; silicon ion, silver ion, sodium ion, strontium ion; sulfate ion, tantalum ion, tellurium ion, terbium ion, thallium ion; thorium ion; thulium ion, tin ion, titanium ion, tungsten ion, vanadium ion; ytterbium ion, yttrium ion; zinc ion, and zirconium ion. 
     
     
         53 . An apparatus for producing a water cluster comprising
 a hollow cylinder  1218  comprising an enclosed cylinder top  1219 , an enclosed cylinder bottom  1233 ; and an inner surface  1225  defining a hollow chamber;   a nozzle  1222  situated at the center of the cylinder top comprising a proximal portion and a distal portion, the nozzle further comprising
 (i) an intake hole  1221  in the proximal portion of the nozzle connected to a transfer pipe directing flow into the nozzle  1213 ; and 
 (ii) one or more curved bore hole  1227  jet openings  1223  in the distal portion of the nozzle in contact with the hollow chamber; and 
   a drain hole  1227  situated in the cylinder bottom.   
     
     
         54 . The apparatus of  claim 53 , wherein the curved bore hole  1227  jet openings  1223  are oriented at an angle between about 0 degrees and about 90 degrees relative to a longitudinal axis of the hollow cylinder. 
     
     
         55 . The apparatus of  claim 53 , wherein the hollow cylinder has
 (i) an inner width of between about 3 to about 4 inches, about 4 to about 5 inches, about 5 to about 6 inches, about 6 to about 7 inches, or about 7 to about 8 inches; and   (ii) an inner length of between about 8 to about 10 inches, about 10 to about 12 inches, about 12 to about 14 inches, about 14 to about 16 inches, about 16 to about 18 inches, about 18 to about 20 inches, about 20 to about 22 inches, about 22 to about 24 inches, or about 24 to about 26 inches.