Therapeutic compounds and methods of use

Abstract

The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C disorders, including diseases and disorders mediated by GPCRs.

1 - 8 . (canceled) 
     
     
         9 . A method of inhibiting 5-HT2C in a subject identified as in need of such treatment, comprising administering a APT compound of the formula: 
       
         
           
           
               
               
           
         
         wherein, 
         R 1  is independently 3-halophenyl, 3-haloalkylphenyl or 3-alkoxyphenyl, wherein the 3-halophenyl, 3-haloalkylphenyl, or 3-alkoxyphenyl are each optionally substituted with 1, 2, or 3 independent halo, alkoxy, or CF 3 ; 
         R 2  is H; 
         or salt, hydrate or solvate thereof. 
       
     
     
         10 - 14 . (canceled) 
     
     
         15 . A compound of the formula: 
       
         
           
           
               
               
           
         
       
       wherein,
 R 1  is independently 3-halophenyl, 3-haloalkylphenyl, or 3-alkoxyphenyl, wherein the 3-halophenyl, 3-haloalkylphenyl, or 3-alkoxyphenyl are each optionally substituted with 1, 2, or 3 independent halo, alkoxy, or CF 3 ; and 
 R 2  is H; 
 
       or salt, hydrate or solvate thereof. 
     
     
         16 . (canceled) 
     
     
         17 . A composition comprising a compound of  claim 15 , or salt hydrate or solvate thereof, and a pharmaceutically acceptable carrier. 
     
     
         18 . A method of making a composition of  claim 17  comprising a compound of  claim 15 , or salt, hydrate or solvate thereof, and a pharmaceutically acceptable carrier. 
     
     
         19 . The compound of  claim 15 , or salt, hydrate or solvate thereof, wherein R 1  is 3-halophenyl optionally substituted with 1, 2, or 3 independent halo, alkoxy, or CF 3 . 
     
     
         20 . The compound of  claim 15 , or salt, hydrate or solvate thereof, wherein R 1  is 3-haloalkylphenyl optionally substituted with 1, 2, or 3 independent halo, alkoxy, or CF 3 . 
     
     
         21 . The compound of  claim 15 , or salt, hydrate or solvate thereof, wherein R 1  is 3-alkoxyphenyl optionally substituted with 1, 2, or 3 independent halo, alkoxy, or CF 3 . 
     
     
         22 . The compound of  claim 15 , or salt, hydrate or solvate thereof, wherein R 1  is 3-halophenyl, 3-haloalkylphenyl, or 3-alkoxyphenyl. 
     
     
         23 . The compound of  claim 15 , or salt, hydrate or solvate thereof, wherein R 1  is 3-halophenyl. 
     
     
         24 . The compound of  claim 15 , or salt, hydrate or solvate thereof, wherein R 1  is 3-haloalkylphenyl. 
     
     
         25 . The compound of  claim 15 , or salt, hydrate or solvate thereof, wherein R 1  is 3-alkoxyphenyl. 
     
     
         26 . The compound of  claim 15 , or salt, hydrate or solvate thereof, wherein R 1  is 3-chlorophenyl. 
     
     
         27 . The compound of  claim 15 , or salt, hydrate or solvate thereof, wherein R 1  is 3-CF 3 -phenyl. 
     
     
         28 . The compound of  claim 15 , or salt, hydrate or solvate thereof, wherein R 1  is 3-methoxyphenyl. 
     
     
         29 . The method of  claim 9 , wherein R 1  is 3-halophenyl. 
     
     
         30 . The method of  claim 9 , wherein R 1  is 3-haloalkylphenyl. 
     
     
         31 . The method of  claim 9 , wherein R 1  is 3-alkoxyphenyl. 
     
     
         32 . The method of  claim 9 , wherein R 1  is 3-chlorophenyl. 
     
     
         33 . The method of  claim 9 , wherein R 1  is 3-CF 3 -phenyl. 
     
     
         34 . The method of  claim 9 , wherein R 1  is 3-methoxyphenyl.