US2020113533A1PendingUtilityA1

Methods for treating idiopathic pulmonary fibrosis

Assignee: FIBROGEN INCPriority: May 3, 2012Filed: Dec 11, 2019Published: Apr 16, 2020
Est. expiryMay 3, 2032(~5.8 yrs left)· nominal 20-yr term from priority
A61B 6/50A61K 2039/505A61B 6/032A61B 6/5217A61K 49/0004A61K 39/3955C07K 16/22
62
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Claims

Abstract

The present invention relates to methods and medicaments useful for treating idiopathic pulmonary fibrosis (IPF) by administering anti-CTGF antibodies. Methods for prognosing individuals with IPF are also provided.

Claims

exact text as granted — not AI-modified
1 - 24 . (canceled) 
     
     
         25 . A method for increasing forced vital capacity (FVC) in a subject with idiopathic pulmonary fibrosis (IPF), the method comprising administering at least 30 mg/kg of an anti-connective tissue growth factor (CTGF) antibody that has the same amino acid sequence as the antibody produced by the cell line identified by ATCC Accession No. PTA-6006, thereby increasing the subject's FVC. 
     
     
         26 . The method of  claim 25 , further comprising the administration of an additional therapeutic agent selected from the group consisting of pirfenidone, nintedanib, corticosteroids, antibiotics, immunosuppressivw drugs and supplemental oxygen.

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