Formulaton of curcumin with enhanced bioavailability of curcumin and method of preparation and treatment thereof

Abstract

A medicinal composition useful for the treatment of head and neck cancer premalignant lesions. The composition includes a curcuminoid mixture and an essential oil of turmeric. The curcuminoid mixture consists of curcumin, demethoxycurcumin and bisdemethoxycurcumin. The essential oil of turmeric includes about 45% ar-turmerone. The weight ratio of curcuminoid mixture to essential oil of turmeric ranges from about 1:3 to about 99:1. Methods of preparation of the composition is provide. Methods of treatment of head and neck cancer premalignant lesions by oral administration is provided.

What is claimed is: 
     
         1 . A composition for enhanced bioavailability of curcumin, the composition comprising a curcuminoid mixture and an essential oil of turmeric, the curcuminoid mixture consisting of curcumin, demethoxycurcumin and bisdemethoxycurcumin, the essential oil of turmeric comprising about 20% ar-turmerone to about 60% ar-turmerone, and wherein a weight ratio of the curcuminoid mixture to the essential oil of turmeric ranges from about 1:3 to about 99:1. 
     
     
         2 . The composition for enhanced bioavailability of  claim 1 , wherein an enhancement of bioavailability of curcumin is at least 2 fold. 
     
     
         3 . The composition for enhanced bioavailability of  claim 1 , wherein the weight ratio of the curcuminoid mixture to the essential oil of turmeric is about 12:1.