US2020102358A1PendingUtilityA1

Methods and compositions related to recombinant neil2

43
Assignee: HAZRA TAPASPriority: Sep 28, 2018Filed: Sep 27, 2019Published: Apr 2, 2020
Est. expirySep 28, 2038(~12.2 yrs left)· nominal 20-yr term from priority
Inventors:Tapas HazraSanjiv SurAshok K. Chopra
C12N 9/22A61P 11/00A61P 31/04C07K 14/47C12N 2015/8518C07K 2319/01C12N 15/85
43
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

Certain embodiments are directed to NEIL2 compositions and method of using NEIL2 composition to treat subjects in need of such treatment.

Claims

exact text as granted — not AI-modified
1 . A NEIL2 polypeptide comprising a NEIL2 polypeptide 80% identical to SEQ ID NO:1 or a segment thereof coupled to a lung targeting moiety. 
     
     
         2 . The NEIL2 polypeptide of  claim 1 , wherein the lung targeting moiety is a peptide. 
     
     
         3 . The NEIL2 polypeptide of  claim 2 , wherein the peptide is a carrier peptide. 
     
     
         4 . The NEIL2 polypeptide of  claim 3 , wherein the carrier peptide consists of the amino acid sequence of SEQ ID NO:9. 
     
     
         5 . The NEIL2 polypeptide of  claim 3 , wherein the NEIL2 polypeptide is 95% identical to SEQ ID NO:1. 
     
     
         6 . The NEIL2 polypeptide of  claim 1 , wherein the NEIL2 polypeptide comprises 300 consecutive amino acids of SEQ ID NO:1. 
     
     
         7 . The NEIL2 polypeptide of  claim 1 , wherein the NEIL2 polypeptide consists essentially of the amino acid sequence of SEQ ID NO:1. 
     
     
         8 . A method of treating an inflammatory condition comprising administering a NEIL2 polypeptide to a subject in need thereof. 
     
     
         9 . The method of  claim 8 , wherein the NEIL2 polypeptide is provided by an expression vector encoding a NEIL2 polypeptide. 
     
     
         10 . The method of  claim 8 , wherein the inflammatory condition is allergic rhinitis, allergic asthma, or inflammation due to a bacterial infection. 
     
     
         11 . A method of treating a bacterial infection comprising administering a NEIL2 polypeptide to a subject in need thereof. 
     
     
         12 . The method of  claim 11 , wherein the NEIL2 polypeptide is provided by an expression vector encoding a NEIL2 polypeptide. 
     
     
         13 . The method of  claim 11 , wherein the bacterial infection is a  Klebsiella  infection. 
     
     
         14 . The method of  claim 11 , wherein the bacterial infection is an  Acinetobacter  infection.

Join the waitlist — get patent alerts

Track US2020102358A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.