Wound dressing materials incorporating anthocyanins derived from fruit or vegetable sources

Abstract

A wound dressing composition, such as gauze, bandages, and surgical tapes comprising a substrate material impregnated with a pH sensitive dye composition comprising at least one anthocyanin derived from fruit or vegetable sources, and methods of use thereof.

1 .- 32 . (canceled) 
     
     
         33 . A method of manufacturing a wound dressing, comprising:
 providing a substrate material; and   disposing pH sensitive dye composition comprising at least one fruit or vegetable derived anthocyanin within the substrate material.   
     
     
         34 . The method of  claim 33 , wherein the at least one anthocyanin is derived from a raspberry ( Rubus  sp.). 
     
     
         35 . The method of  claim 33 , wherein the at least one anthocyanin is derived from a fruit or vegetable selected from the group consisting of a red cabbage, purple cabbage, purple carrots, elderberry, hibiscus, purple potato, red currant, black currants, blueberries, cherries, purple grapes, red raspberries and black raspberries. 
     
     
         36 . The method of  claim 33 , wherein the substrate material is a woven or non-woven material. 
     
     
         37 . The method of  claim 33 , wherein the substrate material comprises a fabric, cloth or sponge material. 
     
     
         38 . The method of  claim 33 , where the substrate material comprises natural or synthetic fibers. 
     
     
         39 . The method of  claim 33 , where the substrate material is an absorbent or water-permeable material. 
     
     
         40 . The method of  claim 33 , where the substrate material comprises cotton. 
     
     
         41 . The method of  claim 33 , wherein substrate material comprises cotton gauze. 
     
     
         42 . The method of  claim 33 , wherein the wound dressing is selected from the group consisting of a pad, wrap, bandage, tape, cotton-tipped stick and adhesive strip bandage. 
     
     
         43 . The method of  claim 33 , wherein the at least one anthocyanin is selected from the group consisting of cyaniding-3-sophoraside, cyanide-3-glucoside or pelargonidin-3-sophoroside. 
     
     
         44 . The method of  claim 33 , wherein the at least one anthocyanin is an anthocyanadin derivative selected from the group consisting of cyandin, delphinidin, peonidin, petunidin, pelargonidin and malvidin anthocyanadin derivatives. 
     
     
         45 . The method of  claim 33 , wherein the pH sensitive dye composition is sensitive at least within a pH range of pH 4.0 to pH 12.0, inclusive. 
     
     
         46 . The method of  claim 33 , wherein the method further comprises disposing at least one therapeutic agent selected from the group consisting of antimicrobial agents, antiseptic agents, anti-inflammatory agents, pain relieving agents, wound closing adhesive agents, and antihistamine agents on the wound dressing. 
     
     
         47 . The method of  claim 33 , wherein the pH sensitive dye composition comprises a mordant. 
     
     
         48 . The method of  claim 47 , wherein the mordant is selected from the group consisting of aluminum potassium sulfate, copper sulfate, iron (III) oxide, copper sulfate, citric acid, iron (III) sulfate (Fe 2 (SO 4 ) 3 ) and sodium sulfate. 
     
     
         49 . The method of  claim 47 , wherein the mordant is aluminum potassium sulfate.