Systems and methods for optimizing diagnostics and therapeutics with metabolic profiling

Abstract

The present disclosure is directed towards methods for calculating disease progression rates and sojourn times of solid tumors from metabolic markers and using this calculation to optimize patient-specific diagnosis, scheduling of screening procedures, and dosage or frequency of treatment.

What is claimed is: 
     
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         9 . A method for optimizing diagnostics and therapeutic procedures for solid tumors in a human patient by measuring metabolic markers during exercise, the method comprising the steps of: measuring the level of at least one metabolic marker in a patient during exercise; and calculating disease progression rates and sojourn times based on a functional relation between at least one metabolic marker and disease progression rates and sojourn time; predicting at least one incident selected from the group consisting of: diagnosis, timing of screening procedures, a type of treatment, a dosage of treatment, a timing of treatment, and a frequency of treatment. 
     
     
         10 . The method of  claim 1 , further comprising the steps of: providing the patient with an exercising equipment; allowing the patient to exercise on the exercising equipment for a period of time. 
     
     
         11 . The method of  claim 2 , further comprising the step of adjusting an exercise level of the patient to the patient's age and heart rate. 
     
     
         12 . The method of  claim 1 , further comprising the step of entering the measurement of the at least one metabolic marker to an algorithm. 
     
     
         13 . The method of  claim 1 , wherein the at least one metabolic marker comprises of glucose, lactate, or pyruvate. 
     
     
         14 . The method of  claim 1 , wherein the patient has been fasting for at least 8 hours. 
     
     
         15 . The method of  claim 1 , wherein the measurement is done by a finger stick blood draw, sweat draw or saliva draw. 
     
     
         16 . The method of  claim 1 , wherein the optimization of the timing and frequency of screening or diagnostics procedures, or the dosage, timing and frequency of treatment, or the dosage, timing and frequency of a therapeutic procedure is done with an algorithm that calculates the patient's metabolic score from the measured metabolic marker; then calculates the potential progression rate and sojourn time from the patient's metabolic score; then uses the calculated progression rate and sojourn time to calculate the personalized timing and frequency of screening or diagnostics procedures, or the personalized dosage, timing and frequency of treatment, or the personalized dosage, timing and frequency of a therapeutic procedure.