US2020072832A1PendingUtilityA1

Methods and Systems for Modulating Hormones and Related Methods, Agents and Compositions

59
Assignee: CALIFORNIA INST OF TECHNPriority: Jun 17, 2010Filed: Jun 24, 2019Published: Mar 5, 2020
Est. expiryJun 17, 2030(~3.9 yrs left)· nominal 20-yr term from priority
Inventors:William A. Goddard, IiiMark MennaStephen PandolRavinder Abrol
A61P 9/00A61P 43/00A61P 3/10A61P 3/00A61P 3/04A61P 1/16A61K 31/167A61K 31/4745A61K 31/353A61K 31/365A61K 31/12A61K 31/122A61K 31/7016A61K 31/10A61K 31/513G01N 33/566A61K 47/61A61K 31/704G01N 2333/705A61K 31/17A61K 31/205A61K 31/4375A61K 31/352
59
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Claims

Abstract

Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.

Claims

exact text as granted — not AI-modified
What is claimed is 
     
         1 . A method for modulating release of a metabolic hormone m an individual, the method comprising
 administering to the individual one or more GI bitter taste receptor ligands selected from PTU, PTC, denatonium benzoate, Glycyrrhizic acid ammonium salt, Epigallocatechin gallate, Hyperforin, Berberine chloride, Coptisine Chloride, Allyl methyl sulfide, Rottlerin, Curcumin, Ellagic acid, Embelin and/or or a derivative thereof, in an effective amount to allow binding of the one or more GI bitter taste receptor ligands to the one or more GI bitter taste receptors in the individual, the binding resulting in modulating release of metabolic hormone GLP-1, PYY and/or CCK.

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