Methods and compositions for inhibiting cd32b expressing cells

Abstract

The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.

We claim: 
     
         1 . A method of treating cancer in a patient in need of such treatment, comprising:
 administering to the patient an anti-human CD40 antibody comprising a light chain and a heavy chain, the heavy chain comprising a human IgG1 Fc domain comprising a S267E amino acid substitution, wherein the numbering is according to the EU index as in Kabat.   
     
     
         2 . The method of  claim 1 , wherein the cancer is pancreatic cancer. 
     
     
         3 . The method of  claim 1 , comprising administering the anti-human CD40 antibody in combination with one or more chemotherapeutic agents. 
     
     
         4 . The method of  claim 3 , wherein the chemotherapeutic agent is gemcitabine. 
     
     
         5 . The method of  claim 4 , wherein the one or more chemotherapeutic agents are gemcitabine in combination with paclitaxel. 
     
     
         6 . The method of  claim 4 , comprising administering the anti-human CD40 antibody in combination with a second antibody. 
     
     
         7 . The method of  claim 5 , comprising administering the anti-human CD40 antibody in combination with a second antibody.