Methods for assessing repellant quality of organic materials and methods and compositions for repelling arthropods

Abstract

The disclosure provides compounds useful as insect repellents, compositions comprising such repellents, and methods of repelling an arthropod using such compounds and compositions. The disclosure further provides insect traps and method for identifying ligands and cognates for biological molecules.

1 . A method of repelling an arthropod, comprising exposing the arthropod with a repelling composition, wherein the repelling composition comprises one or more compounds selected from the group consisting of methyl N,N-dimethyl anthranilate, ethyl anthranilate, butyl anthranilate, and 2,3-dimethyl-5-isobutyl pyrizine. 
     
     
         2 . The method of  claim 1 , wherein the repelling composition further comprises one or more compounds from Table 1. 
     
     
         3 . The method of  claim 1 , wherein the repelling composition further comprises one or more compounds from Table 2. 
     
     
         4 - 7 . (canceled) 
     
     
         8 . A method of repelling an arthropod, comprising exposing the arthropod with a repelling composition, wherein the repelling composition comprises a compound of formula I: 
       
         
           
           
               
               
           
         
         wherein: 
         R 1  is selected from the group consisting of H, C1-C12 alkyl, C2-C12 alkenyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, and cycloakenylalkyl; 
         R 2  and R 3  are each independently selected from the group consisting of H, C1-C12 alkyl, benzoyl, cycloalkyl, cycloalkylalkyl, cycloakenyl, cycloakenylalkyl, arylalkyl, formyl, acyl, and R 2  and R 3  taken together form an ═C—R 8 ; 
         R 4 , R 5 , R 6 , and R 7  are each independently selected from the group consisting of H, C1-C4 alkyl, halo, and alkoxy; and 
         R 8  is C1-C12 akyl, C2-C12 alkenyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, cycloakenyl, and cycloakenylalkyl. 
       
     
     
         9 . The method of  claim 8 , wherein R 1  is C1-C4 alkyl. 
     
     
         10 . The method of  claim 8 , wherein R 1  is CH 3 , CH 2 CH 3 , or CH 2 CH 2 CH 2 CH 3 . 
     
     
         11 . The method of  claim 8 , wherein R 1  is CH 3 , CH 2 CH 3 , or CH 2 CH 2 CH 2 CH 3  and R 2  and R 3  is H. 
     
     
         12 . The method of  claim 8 , wherein the compound of formula I is methyl N,N-dimethyl anthranilate, ethyl anthranilate, or butyl anthranilate. 
     
     
         13 . The method of  claim 1 , wherein the repelling composition is applied on the body of one or more vertebrates or one or more plants to expose the repelling composition to the arthropod. 
     
     
         14 . The method of  claim 13 , wherein the repelling composition is formulated as a lotion, cream, dust, cosmetic, perfume, spray, paste, slow-release granule, paint, treated clothing, treated netting, treated building material, or incense. 
     
     
         15 . The method of  claim 1 , wherein the exposing the arthropod with the repelling composition is carried out using a vaporizer, evaporator, fan, heat, candle, or wicked apparatus. 
     
     
         16 . The method of  claim 1 , wherein the arthropod is an insect. 
     
     
         17 . The method of  claim 1 , wherein the arthropod is of the order Diptera. 
     
     
         18 . The method of  claim 17 , wherein the arthropod is of the genus  Drosophila.    
     
     
         19 . The method of  claim 1 , wherein the arthropod is a mosquito. 
     
     
         20 . The method of  claim 19 , wherein the mosquito is of the species  Aedes aegypti.    
     
     
         21 . (canceled)