US2020046743A1PendingUtilityA1

Salts of prodrugs of piperazine and substituted piperidine antiviral agents

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Assignee: VIIV HEALTHCARE UK NO 4 LTDPriority: Mar 15, 2004Filed: Oct 22, 2019Published: Feb 13, 2020
Est. expiryMar 15, 2024(expired)· nominal 20-yr term from priority
Inventors:Yasutsugu UedaTimothy P. ConnollyJohn F. KadowNicholas A. MeanwellTao WangChung-Pin H. ChenKap-Sun YeungZhongxing ZhangDavid K. LeahyShawn K. PackNachimuthu SoundararajanPierre SirardKathia LevesqueDominique Thoraval
A61P 31/12A61P 43/00A61P 31/18C07F 9/65586A61K 45/06C07F 9/65515A61K 31/675C07F 9/6561C07F 9/5728A61K 31/497A61K 31/519C07D 471/04C07C 215/10C07F 9/062C07F 9/09
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Claims

Abstract

This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R 1 does not exist; W is C or N with the proviso that when W is N, R 2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C 1 -C 6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . The compound

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