Composition comprising recombinant fusion protein of pathogenic antigen protein and flagellin of vibrio vulnificus for preventing, alleviating, or treating aging

Abstract

The present invention relates to a composition for preventing, improving, or treating aging, wherein the composition comprises a recombinant protein of flagellin, which is the constituent of Vibrio vulnificus flagella, fused with a pathogenic protein antigen, as an active component. According to the present invention, the recombinant protein of the present invention can improve external and internal aging-related malfunctions and enhance immunity. Also, the composition of the present invention can easily perform immunization through mucosal administration.

1 - 11 . (canceled) 
     
     
         12 . A method for preventing, improving, or treating metabolic disease, the method comprising administering to a subject the composition comprising a recombinant protein of flagellin, which is the constituent of  Vibrio vulnificus  flagella, fused with a pathogenic protein antigen, as an active ingredient. 
     
     
         13 . The method according to  claim 12 , wherein the flagellin is FlaB, which is flagellin of  Vibrio vulnificus.    
     
     
         14 . The method according to  claim 12 , wherein the pathogenic protein antigen is surface protein A (PspA) of  Streptococcus pneumonia.    
     
     
         15 . The method according to  claim 12 , wherein the recombinant protein is FlaB-PspA protein having an amino acid sequence of SEQ ID NO: 1. 
     
     
         16 . The method according to  claim 12 , wherein the recombinant protein enhances immunity. 
     
     
         17 . The method according to  claim 12 , wherein the metabolic disease is caused by aging. 
     
     
         18 . The method according to  claim 12 , wherein the metabolic disease is a syndrome in which risk factors, such as obesity, diabetes, hypertriglyceridemia, hypertension, cardiovascular disease, and blood clotting, are shown together.