Methods for the treatment of hyperhidrosis

Abstract

The present invention relates in general to methods of treating sweating disorders and in particular to topical compositions for the treatment of hyperhidrosis. The methods of the present invention relate to the topical application of a composition comprising a therapeutically effective amount of oxybutynin, tolterodine or a substituted benzamide such as sulpiride.

What is claimed is: 
     
         1 . A method for treating hyperhidrosis and/or for inhibiting perspiration and/or apocrine sweating, the method comprising administering to a subject in need thereof a composition comprising a therapeutically effective amount of a substituted benzamide. 
     
     
         2 . The method of  claim 1 , wherein said substituted benzamide is selected from the group consisting of sulpiride, metoclopramide, tiapride and sultopride. 
     
     
         3 . The method of  claim 1 , wherein said administering is effected by oral or buccal administration. 
     
     
         4 . The method of  claim 3 , being for treating hyperhidrosis. 
     
     
         5 . The method of  claim 1 , wherein said administering is effected by topical administration of a composition comprising said substituted benzamide and a dermatologically acceptable excipient or carrier. 
     
     
         6 . The method of  claim 1 , wherein said substituted benzamide is sulpiride. 
     
     
         7 . The method of  claim 6 , wherein said administering is effected by oral or buccal administration. 
     
     
         8 . The method of  claim 7 , being for treating hyperhidrosis. 
     
     
         9 . The method of  claim 7 , wherein said therapeutically effective amount is in a range of from 10 mg per day to 1000 mg per day. 
     
     
         10 . The method of  claim 9 , wherein said therapeutically effective amount is in a range of from 100 mg per day to 600 mg per day. 
     
     
         11 . The method of  claim 6 , wherein said administering is effected by topical administration of a composition comprising sulpiride and a dermatologically acceptable excipient or carrier. 
     
     
         12 . The method of  claim 11 , wherein a concentration of sulpiride in said composition is in a range of from 0.01 to 5% (w/v). 
     
     
         13 . The method according to  claim 11 , wherein the composition is in a form selected from the group consisting of an aqueous solution, a non-aqueous solution, lotion, cream, gel, oil, ointment, foam, mousse, spray, an emulsion, a shampoo, soap and microemulsion. 
     
     
         14 . The method according to  claim 13 , wherein the composition is a gel or foam. 
     
     
         15 . The method according to  claim 14 , wherein said gel comprises aloe vera extract or aloe vera gel. 
     
     
         16 . The method according to  claim 11 , wherein the composition does not include a permeation enhancer. 
     
     
         17 . The method according to  claim 11 , wherein said therapeutically effective amount of said sulpiride is comprised by an article selected from the group consisting of a garment, footwear and headgear. 
     
     
         18 . A composition for treating hyperhidrosis and/or for inhibiting perspiration and/or apocrine sweating, the composition comprising a therapeutically effective amount of a substituted benzamide. 
     
     
         19 . A composition for treating hyperhidrosis and/or for inhibiting perspiration and/or apocrine sweating, the composition comprising a therapeutically effective amount of a compound selected from the group consisting of oxybutynin and tolterodine. 
     
     
         20 . A method for treating hyperhidrosis and/or for inhibiting perspiration and/or apocrine sweating, the method comprising administering to a subject in need thereof the composition of  claim 19 .