Composition and methods for tissue regeneration

Abstract

Described herein are topical compositions containing an effective amount of propylene glycol, as a sole active ingredient or a principal active ingredient, and a pharmaceutically acceptable medium. Also described herein are methods of promoting the growth of or the regeneration of a tissue such as nail, hair, gum and skin in humans by topically administering the topical compositions to a human in need thereof.

What is claimed is: 
     
         1 . A topical composition for reducing or preventing the gum recession or promoting the gum growth or regenerating new gum in a human comprising:
 a gum-growth-promoting agent consisting of from about 1% to about 99% by weight of propylene glycol and   a pharmaceutically acceptable medium;   wherein the topical composition is to be applied to the gum area as a uniform layer or to be injected topically into various gum areas, wherein the composition is selected from the group consisting of a liquid solution, liquid mixture, suspension, lotion, paste, gel, cream, foam, spray, dressing and an emulsion.   
     
     
         2 . The composition of  claim 1 , wherein the concentration of propylene glycol ranges from about 3% to about 95% by weight or about 10% to about 95% by weight. 
     
     
         3 . The composition of  claim 1 , wherein the concentration of propylene glycol ranges from about 20% to about 95% by weight or about 40% to about 95% by weight. 
     
     
         4 . The composition of  claim 1 , wherein the concentration of propylene glycol ranges from about 30% to about 95% by weight. 
     
     
         5 . The composition of  claim 1 , wherein the pharmaceutically acceptable medium contains an ingredient selected from the group consisting of water, glycerin, dimethyl sulfoxide, other solvent, an electrolyte, a pH modifier, a surfactant, an absorption enhancer, an emulsifier, a thickener, a fragrance, a color, a preservative, and combinations thereof. 
     
     
         6 . A method for reducing or preventing the gum recession or promoting the gum growth or regenerating new gum in a human comprising:
 administering to the gum of the human in need thereof an effective amount of the composition of  claim 1 .   
     
     
         7 . A method for enhancing the growth of and/or for regenerating of a topical tissue in a human, said method comprised of applying to the human in need thereof a composition comprising:
 an effective concentration of propylene glycol and   a pharmaceutically acceptable medium containing an ingredient selected from the group consisting of water, glycerin, dimethyl sulfoxide, a solvent, electrolyte, pH modifier, surfactant, absorption enhancer, emulsifier, thickener, fragrance, preservative, salicylic acid, sodium salicylate, an emulsifier and combinations thereof, and, and   optionally, a cell-growth promoter;   wherein the composition is selected from the group consisting of a liquid solution, liquid mixture, suspension, lotion, paste, gel, cream, foam, spray, dressing and an emulsion; and   wherein the dosage form is applied topically to the tissue of the human to be treated.   
     
     
         8 . The method of  claim 7 , wherein the topical tissue is a scalp. 
     
     
         9 . The method of  claim 7 , wherein the topical tissue is an eyebrow, an eyelash, a skin or a wounded skin. 
     
     
         10 . The method of  claim 7 , wherein the topical tissue is a burned skin. 
     
     
         11 . The method of  claim 7 , wherein the topical tissue is a nail. 
     
     
         12 . The method of  claim 7 , wherein the composition contains the cell-growth promoter in an amount that ranges from about 0.001% to about 30% by weight, wherein the cell-growth promoter is selected from the group consisting of biotin, one or more other water-soluble vitamins, aloe vera powder, aloe vera gel, arginine, arginine hydrochloride, dimethyl sulfoxide, sodium chloride, zinc chloride, magnesium chloride, magnesium sulfate, salicylic acid, sodium salicylate, and combinations thereof.