Use of carbamate compound in order to preventatively treat headaches

Abstract

The present invention relates to a pharmaceutical composition for preventatively treating headaches, containing: a carbamate compound of chemical formula 1 or a pharmaceutically acceptable salt, solvent or hydrate thereof; and a pharmaceutically acceptable carrier. According to the present invention, the pharmaceutical composition can effectively prevent a headache, more specifically, headaches caused by cortical spreading depression, and particularly, chronic headaches including migraines.

1 . A medicament for the prophylactic treatment of headaches, comprising a therapeutically effective amount of a carbamate compound of the following Formula 1, or a pharmaceutically acceptable salt, solvate or hydrate thereof: 
       
         
           
           
               
               
           
         
         wherein, 
         R 1  and R 2  are each independently selected from the group consisting of hydrogen, halogen, C 1 -C 8  alkyl, halo-C 1 -C 8  alkyl, C 1 -C 8  thioalkoxy and C 1 -C 8  alkoxy; and 
         one of A 1  and A 2  is CH, and the other is N. 
       
     
     
         2 . The medicament according to  claim 1 , wherein R 1  and R 2  are each independently selected from the group consisting of hydrogen, halogen and C 1 -C 8  alkyl. 
     
     
         3 . The medicament according to  claim 1 , wherein the carbamate compound of Formula 1 is carbamic acid (R)-1-(2-chlorophenyl)-2-tetrazol-2-yl)ethyl ester of the following Formula 2: 
       
         
           
           
               
               
           
         
       
     
     
         4 . The medicament according to  claim 1 , wherein the headache is a headache associated with cortical spreading depression (CSD). 
     
     
         5 . The medicament according to  claim 1 , wherein the headache is chronic headache. 
     
     
         6 . The medicament according to  claim 1 , wherein the headache is migraine. 
     
     
         7 . The medicament according to  claim 6 , wherein the migraine is migraine with aura. 
     
     
         8 - 22 . (canceled) 
     
     
         23 . A method for prophylactically treating headaches in a subject, comprising:
 administering a therapeutically effective amount of a carbamate compound of Formula 1, or a pharmaceutically acceptable salt, solvate or hydrate thereof to the subject:   
       
         
           
           
               
               
           
         
         wherein, 
         R 1  and R 2  are each independently selected from the group consisting of hydrogen, halogen, C 1 -C 8  alkyl, halo-C 1 -C 8  alkyl, C 1 -C 8  thioalkoxy and C 1 -C 8  alkoxy; and 
         one of A 1  and A 2  is CH, and the other is N. 
       
     
     
         24 . The method according to  claim 23 , wherein R 1  and R 2  are each independently selected from the group consisting of hydrogen, halogen and C 1 -C 8  alkyl. 
     
     
         25 . The method according to  claim 23 , wherein the carbamate compound of Formula 1 is carbamic acid (R)-1-(2-chlorophenyl)-2-tetrazol-2-yl)ethyl ester of Formula 2: 
       
         
           
           
               
               
           
         
       
     
     
         26 . The method according to  claim 23 , wherein the headache is headache associated with cortical spreading depression (CSD). 
     
     
         27 . The method according to  claim 23 , wherein the headache is chronic headache. 
     
     
         28 . The method according to  claim 23 , wherein the headache is migraine. 
     
     
         29 . The method according to  claim 28 , wherein the migraine is migraine with aura. 
     
     
         30 . The method according to  claim 23 , wherein the subject is a mammal. 
     
     
         31 . The method according to  claim 30 , wherein the mammal is a human. 
     
     
         32 . The method according to  claim 23 , wherein the therapeutically effective amount of the carbamate compound of Formula 1 is 10 to 500 mg based on once-daily administration. 
     
     
         33 - 40 . (canceled) 
     
     
         41 . The method according to  claim 23 , wherein the carbamate compound of Formula 1, or a pharmaceutically acceptable salt, solvate or hydrate thereof is administered orally, parenterally, intravenously, intramuscularly, subcutaneously or rectally.