Intervertebral fusion device comprising an intervertebral stabilising screw and a composition for bone remodelling

Abstract

The invention relates to an intervertebral fusion device comprising an intervertebral stabilizing screw and a composition for bone remodeling. The intervertebral stabilizing screw comprises: a main body with an axial through-hole and a distal thread that is secured to the bone, located at a distal end of the main body; a hollow proximal secondary body that can slide along the length of the main body; and a travel stop for the proximal secondary body, located on an outer surface of the main body. According to the invention, the proximal secondary body also includes an external thread for securing to the bone, and the main body comprises at least one fill hole, located between the distal thread and the travel stop, for connecting an intervertebral space to the aforementioned axial hole.

1 . An intervertebral stabilizing screw comprising a main body with an axial through hole and a distal thread for securing to the bone, located at a distal end of the main body, a hollow proximal secondary body that can slide along the length of the main body and a travel stop for the proximal secondary body, located on an outer surface of the main body,
 wherein the proximal secondary body also includes an external thread for securing to the bone, and   said main body comprises at least one fill hole, located between the distal thread and said stop, for connecting an intervertebral space to said axial hole.   
     
     
         2 . The screw, according to  claim 1 , wherein the external diameter of the thread of the proximal secondary body is greater than the diameter of the distal thread. 
     
     
         3 . The screw, according to  claim 1 , wherein said stop consists of a step which impedes the travel of the proximal secondary body up to said fill. 
     
     
         4 . The screw, according to  claim 3 , wherein the step is formed by a variation in the external diameter of the main body. 
     
     
         5 . The screw, according to  claim 1 , wherein said screw comprises at least two fill holes. 
     
     
         6 . The screw, according to  claim 1 , wherein said fill hole or holes has or have a radial course. 
     
     
         7 . The screw, according to  claim 6 , wherein said fill hole or holes has or have a diametric course, with two outlets that connect opposite points of the wall of the main body. 
     
     
         8 . The screw, according to  claim 1 , wherein both the main body and the proximal secondary body have at the proximal end thereof devices for receiving a percutaneous tool. 
     
     
         9 . The screw, according to  claim 1 , further comprising a proximal cover to close off access to the axial hole once the screw is installed. 
     
     
         10 . The screw, according to  claim 1 , wherein the main body and the proximal secondary body are threaded together, in such a way that said sliding along the length of the main body comprises a relative rotation therebetween. 
     
     
         11 . A composition for bone remodelling comprising:
 polymerizable bone cement,   a calcium phosphate provider, and   an oxygen providing compound.   
     
     
         12 . The composition, according to  claim 1  further comprising an osteogenic factor. 
     
     
         13 . The composition, according to  claim 11  further comprising a contrast agent. 
     
     
         14 . The composition, according to  claim 11 , wherein the oxygen providing compound is selected from the group consisting of oxygenated water, ozone and an oxygen solution. 
     
     
         15 . The composition, according to  claim 14 , wherein the oxygen provider is oxygenated water. 
     
     
         16 . The composition, according to  claim 11 , wherein the polymerizable e bone cement comprises a polymer selected from the group made up of poly(methyl methacrylate) (PMMA), bisphenol A glycidyl methacrylate (bis GMA) and poly(lactic co glycolic acid) (PLGA). 
     
     
         17 . The composition, according to  claim 16 , wherein the polymerizable e bone cement comprises PMMA. 
     
     
         18 . The composition, according to  claim 11 , wherein the calcium phosphate provider is hydroxyapatite, brushite or tricalcium phosphate. 
     
     
         19 . The composition, according to  claim 18 , wherein the calcium phosphate provider is hydroxyapatite. 
     
     
         20 . The composition, according to  claim 11 , wherein the osteogenic factor is selected from blood derived growth factors, whole blood or osteogenic stem cells. 
     
     
         21 . The composition, according to  claim 20 , wherein the osteogenic factor is a blood derived growth factor. 
     
     
         22 . The composition, according to  claim 11 , wherein the contrast factor is a non ionic contrast factor. 
     
     
         23 . The composition, according  claim 11 , wherein the polymerizable bone cement is present in a quantity of between 55% and 80% by weight of the composition. 
     
     
         24 . The composition, according to  claim 11 , wherein the calcium phosphate provider is present at between 15% and 30% by weight of the composition. 
     
     
         25 . The composition, according to  claim 11 , wherein the oxygen providing compound is present in a quantity equal to or less than 5% by weight. 
     
     
         26 . The composition, according to  claim 12 , wherein the osteogenic factor is present in a quantity of less than 5% by weight. 
     
     
         27 . The composition, according to  claim 13 , wherein the contrast agent is present in a quantity of less than 1% by weight. 
     
     
         28 . An intervertebral fusion device comprising:
 at least one vertebral stabilizing screw according to  claim 1  and   a composition for bone remodeling, which comprises:
 polymerizable bone cement, 
 a calcium phosphate provider, and 
 an oxygen providing compound. 
   
     
     
         29 . The device, according to  claim 28 , comprising at least two of said vertebral stabilizing screws.