Preparative liquid chromatograph

Abstract

A preparative liquid chromatograph includes a liquid chromatograph section, a trap section, an eluent supply section, a collector, and a flow path switching section. The flow path switching section is configured to be selectively switched to a component trap mode that connects the liquid chromatograph section and the trap section in such a way that a sample component separated in a separation column is trapped by a trap column of the trap section; and a collection mode that connects the eluent supply section and the trap section and connects the trap section and the collector in such a way that the components trapped in the trap column are eluted by an eluent from the eluent supply section and are guided to the collector.

1 - 7 . (canceled) 
     
     
         8 . A preparative liquid chromatograph comprising:
 a liquid chromatograph section comprising a sample injection part, a separation column, and a detector, wherein the liquid chromatograph section is configured in such a way that a sample injected by the sample injection part is separated into components in the separation column and the separated components are detected by the detector;   a trap section that includes one or more trap columns and is configured in such a way that the components separated in the separation column are trapped by the trap columns;   an eluent supply section for supplying an eluent for eluting the components trapped in the trap columns from the trap columns;   a collector for collecting the eluate from the trap columns;   a flow path switching section configured to be selectively switched to a component trap mode and a collection mode, wherein the component trap mode is a mode where the liquid chromatograph section and the trap section are connected to each other in such a way that the components separated in the separation column are trapped by the trap columns, and wherein the collection mode is a mode where the eluent supply section and the trap section are connected to each other, and the trap section and the collector are connected to each other in such a way that the components trapped in the trap columns are eluted from the trap columns by the eluent supplied by the eluent supply section and are led to the collector;   a control section that controls the operations of the liquid chromatograph section, the trap section, the eluent supply section, the collector, and the flow path switching section, and   wherein the control section includes a collective trap program that is configured to control the operation of the trap section in such a way that when analyses of the same sample are performed, in multiple times, in the liquid chromatograph section, the same components separated in the separation column are collectively trapped in the common trap column.   
     
     
         9 . The preparative liquid chromatograph according to  claim 8 , wherein the trap section includes a plurality of the trap columns, and
 the collector is configured to fractionate and collect the eluate from each trap column.   
     
     
         10 . The preparative liquid chromatograph according to  claim 8 , further comprising a purifying liquid supply section that supplies a purifying liquid for purifying the components trapped in the trap columns,
 wherein the flow path switching section is configured to be selectively switched also to a purification mode, the purification mode being a mode where the purifying liquid supply section and the trap section are connected to each other in such a way that the components trapped in the trap columns are purified by the purifying liquid supplied by the purifying liquid supply section.   
     
     
         11 . The preparative liquid chromatograph according to  claim 10 , wherein the purifying liquid has a property to remove components that are derived from a mobile phase and are present in the trap columns. 
     
     
         12 . The preparative liquid chromatograph according to  claim 10 , wherein the control section comprises:
 a component trap program that is configured to perform a component trap operation in which desired components separated in the separation column are trapped in the trap columns by switching the flow path switching section to the component trap mode and by controlling an operation of the trap section based on a detection signal of the detector;   a purification program that is configured to perform, after the component trap operation, a purification operation in which by switching the flow path switching section to the purification mode, the components trapped in the trap columns are purified with the purifying liquid from the purifying liquid supply section; and   a collection program that is configured to perform, after the purification operation, a collection operation in which by switching the flow path switching section to the collection mode, the components trapped in the trap columns are eluted by the eluent supplied by the eluent supply section and the eluted components are collected by the collector.