Removable Film Forming Gel Compositions Featuring Adhesion Promoters

Abstract

Film-forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film-forming polymer, an amine-rich adhesion promoter, and a volatile solvent. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing.

1 . A gel composition for use as a conformable film bandage, the gel composition comprising:
 a silicone containing, film-forming polymer;   an amine-rich adhesion promoter; and   a volatile solvent;   wherein a film cast from the gel composition is self-supporting on a biological substrate and can be peeled off the substrate.   
     
     
         2 . The gel composition of  claim 1 , comprising about 5 to about 30 wt. % silicone containing, film-forming polymer;
 about 1 to about 35 wt. % amine-rich adhesion promoter; and   about 50 to about 80 wt. % volatile solvent,   each based on the total weight of the gel composition.   
     
     
         3 . The gel composition of  claim 1 , wherein the silicone containing, film-forming polymer includes at least one of polydiorganosiloxane polyurea, polydiorganosiloxane polyamine, polysiloxane carbonate, polydiorganosiloxane polyamide, and combinations thereof. 
     
     
         4 . The gel composition of  claim 3 , wherein the polydiorganosiloxane polyamide is a polydiorganosiloxane polyamide. 
     
     
         5 . The gel composition of  claim 1 , wherein the amine-rich adhesion promoter has an amine number greater than 25. 
     
     
         6 . (canceled) 
     
     
         7 . The gel composition of  claim 1 , wherein the amine-rich adhesion promoter is at least one of an aminopolymer, an aminosilicone, and chitosan. 
     
     
         8 . The gel composition of  claim 7 , wherein the aminosilicone includes pedant mono- or diamine groups. 
     
     
         9 . The gel composition of  claim 1 , further comprising:
 an MQ silicate tackifying resin.   
     
     
         10 . The gel composition of  claim 1 , further comprising:
 an antiseptic agent, wherein the antiseptic comprises at least one of octenidine, chlorhexidine salt, alexidine salt, polyhexamethylene biguanide salt, benzalkonium salt, cetyl pyridinium salt, cetrimonium salt, or benzethonium salt, and combinations thereof.   
     
     
         11 . The gel composition of  claim 1 , wherein the volatile solvent is selected from the group consisting of volatile linear and cyclic siloxanes, volatile polydimethylsiloxanes, isooctane, octane, and combinations thereof. 
     
     
         12 . The gel composition of  claim 1 , wherein the adhesion promoter comprises polyethylenimine 
     
     
         13 . The gel composition of  claim 1 , wherein the adhesion promoter comprises a silylated polyamine. 
     
     
         14 . The gel composition of  claim 13 , wherein the silylated polyamine is trimethoxysilylpropyl modified polyethylenimine. 
     
     
         15 . The gel composition of  claim 1 , further comprising:
 a filler,   wherein the filler is at least one of kaolin and fumed silica.   
     
     
         16 . The gel composition of  claim 1 , substantially free of one or both of a tackifier and a coagulant. 
     
     
         17 . A self-supporting film cast from the composition of  claim 1 , wherein the self-supporting film exhibits an elongation of at least 100% and an ultimate tensile strength of at least 0.3 MPa after drying on a biological substrate. 
     
     
         18 . The self-supporting film of  claim 17 , wherein the film exhibits an upright MVTR of at least 300 g/m 2 /24 hours and a Skin Adhesion of at least 50 g/inch and no greater than 900 g/inch. 
     
     
         19 . The self-supporting film of  claim 17 , wherein at least a portion of the self-supporting film has a thickness of at least 2 mils and no greater than 20 mils. 
     
     
         20 . The self-supporting film of the  claim 19 , wherein the self-supporting film comprises:
 (a) 50-75 wt. % film-forming polymer;   (b) 0.1-30 wt. % filler; and   (c) 10-60 wt. % amine-rich adhesion promoter, based on the weight of the film.   
     
     
         21 . The self-supporting film of  claim 16 , further comprising:
 about 15 to about 35 wt. % tackifier, based on the weight of the self-supporting film.