Onset-mitigating high-frequency nerve block

Abstract

A method of blocking signal transmission through a nerve with reduced onset activity includes applying an HFAC to an axon of a nerve to block the transmission of signals through the axon. The method may also include applying a direct current (DC) to the axon, increasing the amplitude of the DC over time to a predetermined amplitude, applying the HFAC, and then decreasing the DC. The method may also include temporarily reducing the amplitude of the HFAC to permit the transmission of signals through the axon and subsequently increasing the amplitude to block transmission without triggering an onset response. The method may also include temporarily applying an unbalanced charge to the nerve and then balancing the charge over time.

1 .- 38  (canceled) 
     
     
         39 . A closed-loop nerve block system, the system comprising:
 at least one sensor to detect a signal from a biological component, wherein the signal is indicative of pain;   a controller coupled to the at least one sensor and configured to receive an indication of the signal from the at least one sensor, the controller further comprising a processor to determine whether nerve block is required by the biological process based on the signal from the at least one sensor;   a waveform generator coupled to the controller and configured to generate a nerve block signal when the processor indicates that the nerve block is required, the nerve block signal having a frequency of greater than 1 kHz and an amplitude of approximately 4 to 10 volts per pulse; and   one or more electrodes coupled to the waveform generator and configured to apply the nerve block signal to a nerve associated with the biological process, wherein the controller is configured to apply the nerve block signal to the one or more electrodes when the processor indicates that nerve block is required.   
     
     
         40 . The system of  claim 39 , wherein the pain is related to at least one of neuroma pain, cancer pain, post-operative pain, and chronic pain. 
     
     
         41 . The system of  claim 39 , further comprising at least two sensors, each to detect different signals from one or more biological components. 
     
     
         42 . The system of  claim 39 , wherein the controller is coupled to the at least two sensors and the processor determines whether nerve block is required by the biological process based on indications of the different signals from the at least two sensors. 
     
     
         43 . The system of  claim 42 , wherein the one or more electrodes each comprises at least two contacts, and the controller instructs a respective one of the at least two contacts to apply the nerve block signal based on the indications of the different signals from the at least two sensors. 
     
     
         44 . The system of  claim 39 , wherein the nerve block is one or more of an efferent neuron block, an afferent neuron block, and an interneuron block. 
     
     
         45 . The system of  claim 39 , wherein the controller signals a switch between the waveform generator and the electrode to close when the controller determines that nerve block is required by the biological process. 
     
     
         46 . The system of  claim 45 , wherein the controller signals the switch to open after expiration of a time for application of the block. 
     
     
         47 . The system of  claim 39 , wherein the controller is configured to adjust one or more of the frequency, voltage and current of the nerve block signal based on the signal from the biological component. 
     
     
         48 . The system of  claim 39  wherein the at least one sensor is configured to detect the signal from a biological component comprising excitation of the nerve. 
     
     
         49 . The system of  claim 39 , wherein the waveform generator is configured to generate a nerve block signal having a current of between 1 milliamp and 12 milliamps. 
     
     
         50 . A closed-loop nerve block method, the method comprising:
 detecting, by a sensor, a signal from a biological component, wherein the signal is indicative of pain;   receiving, by a controller, an indication of the signal from the at least one sensor;   determining, by the controller, whether nerve block is required by the biological process based on the indication of the signal from the at least one sensor;   in response to the controller indicating the nerve block is required, configuring, by a waveform generator, a nerve block signal; and   applying, by one or more electrodes, the nerve block signal to a nerve associated with the biological process, when the controller indicates that the nerve block is required, wherein the nerve block signal comprises blocking waveforms having a frequency of greater than 1 kHz having an amplitude of between 4 to 10 volts per pulse.   
     
     
         51 . The method of  claim 50 , wherein the pain is related to at least one of neuroma pain, cancer pain, post-operative pain, and chronic pain. 
     
     
         52 . The method of  claim 50 , wherein the nerve block is one or more of an efferent neuron block, an afferent neuron block, and an interneuron block. 
     
     
         53 . The method of  claim 50 , further comprising signaling, by the controller, a switch between the waveform generator and the electrode to close when the controller determines that nerve block is required by the biological process. 
     
     
         54 . The method of  claim 53 , further comprising signaling, by the controller, the switch to open after expiration of a time for application of the block. 
     
     
         55 . The method of  claim 50 , further comprising adjusting one or more of the frequency, the amplitude and a current of the nerve block signal based on the signal from the biological component. 
     
     
         56 . The method of  claim 50 , further comprising adjusting one or more of the frequency, the amplitude and a current of the nerve block signal based on the signal from the biological component. 
     
     
         57 . The method of  claim 50 , wherein detecting the signal from the biological component comprises detecting excitation of the nerve. 
     
     
         58 . A closed-loop nerve block system for treating pain, the system comprising:
 at least one sensor to detect a signal from a nerve indicating pain;   a controller coupled to the at least one sensor and configured to receive an indication of the signal from the at least one sensor;   a processor coupled to the controller, the processor configured to trigger application of a nerve block signal based on the signal detected by the at least one sensor;   a waveform generator coupled to the controller configured to generate the nerve block signal when the processor send instructions that the nerve block is required based on the biological process, wherein the nerve block signal has a frequency of greater than 1 kHz and an amplitude of approximately 4 to 10 volts per pulse; and   one or more electrodes coupled to the waveform generator and configured to apply the nerve block signal to the nerve associated with the biological process, wherein the controller is configured to adjust one or more of the frequency, the amplitude and a current of the nerve block signal based on the signal detected by the at least one sensor.