Anticholinergic neuroprotective composition and methods

Abstract

The present invention relates to a pharmaceutical composition comprising propiverine, trospium or glycopyrrolate; and a non-anticholinergic antiemetic agent. It is also related to a pharmaceutical composition comprising a high dose of solifenacin or a pharmaceutically acceptable salts thereof; and a non-anticholinergic antiemetic agent. Pharmaceutical compositions containing high dose of nsPAChA for use for increasing the AChEI blood concentrations and for combating neurodegeneration are also described. The invention also relates to a method for inducing neuroprotection and combating neurodegeneration in a patient suffering from Alzheimer type dementia as well as to a method for increasing the blood levels of an acetyl choline esterase inhibitor (AChEI) in a human subject treated with an AChEI dose.

1 . A pharmaceutical composition comprising a nsPAChA selected from the group consisting of propiverine and pharmaceutically acceptable salts thereof, in an amount which is equivalent to from 15 mg to 120 mg of propiverine hydrochloride; trospium pharmaceutically acceptable salts, in an amount which is equivalent to from 20 mg to 480 mg of trospium chloride; and glycopyrrolium pharmaceutically acceptable salts, in an amount which is equivalent to from 2 mg to 16 mg of glycopyrronium bromide; and (b) a non-anticholinergic antiemetic agent (naAEA); in admixture with a pharmaceutical carrier.