Use of Derivatives of Polyunsaturated Fatty Acids as Medicaments

Abstract

Use of polyunsaturated fatty acid derivatives as medicaments or functional foods. The present invention relates to the use of 1,2-fatty acid derivatives in the treatment or prevention of common diseases whose etiology is based on alterations (of any type) of the cell membrane lipids, for example, changes in levels, in the composition or in the structure of these lipids. In addition, for diseases in which the regulation of lipid composition and of the structure of the membranes (or proteins that interact with membranes) causes the reversion of pathological state.

1 - 16 . (canceled) 
     
     
         17 . A method to treat a cancer in a subject in need thereof comprising administering to the subject an effective amount of a composition comprising at least a polyunsaturated fatty acid selected from the group consisting of
 (i) COOH—CHOH—(CH 2 ) 6 —(CH═CH—CH 2 ) 2 —(CH 2 ) 3 —CH 3  (182A1), an acceptable salt, or a combination thereof;   (ii) COOH—CHOH—(CH 2 ) 6 —(CH═CH—CH 2 ) 3 —CH 3  (183A1), an acceptable salt, or a combination thereof;   (iii) COOH—CHOH—(CH 2 ) 3 —(CH═CH—CH 2 ) 3 —(CH 2 ) 3 —CH 3  (183A2), an acceptable salt, or a combination thereof;   (iv) COOH—CHOH—(CH 2 ) 2 —(CH═CH—CH 2 ) 4 —(CH 2 ) 3 —CH 3  (204A1), an acceptable salt, or a combination thereof;   (v) COOH—CHOH—(CH 2 ) 2 —(CH═CH—CH 2 ) 5 —CH 3  (205A1), an acceptable salt, or a combination thereof;   (vi) COOH—CHOH—CH 2 —(CH═CH—CH 2 ) 6 —CH 3  (226A1), an acceptable salt, or a combination thereof; or,   (vii) a combination thereof.   
     
     
         18 . A method to treat a neurodegenerative disease in a subject in need thereof comprising administering to the subject an effective amount of a composition comprising at least a polyunsaturated fatty acid selected from the group consisting of
 (i) COOH—CHOH—(CH 2 ) 6 —(CH═CH—CH 2 ) 2 —(CH 2 ) 3 —CH 3  (182A1), an acceptable salt, or a combination thereof;   (ii) COOH—CHOH—(CH 2 ) 6 —(CH═CH—CH 2 ) 3 —CH 3  (183A1), an acceptable salt, or a combination thereof;   (iii) COOH—CHOH—(CH 2 ) 3 —(CH═CH—CH 2 ) 3 —(CH 2 ) 3 —CH 3  (183A2), an acceptable salt, or a combination thereof;   (iv) COOH—CHOH—(CH 2 ) 2 —(CH═CH—CH 2 ) 4 —(CH 2 ) 3 —CH 3  (204A1), an acceptable salt, or a combination thereof;   (v) COOH—CHOH—(CH 2 ) 2 —(CH═CH—CH 2 ) 5 —CH 3  (205A1), an acceptable salt, or a combination thereof;   (vi) COOH—CHOH—CH 2 —(CH═CH—CH 2 ) 6 —CH 3  (226A1), an acceptable salt, or a combination thereof; or,   (vii) a combination thereof.