US2019351101A1PendingUtilityA1

Cardiovascular Prostheses

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Assignee: CORMATRIX CARDIOVASCULAR INCPriority: Dec 16, 2011Filed: Aug 5, 2019Published: Nov 21, 2019
Est. expiryDec 16, 2031(~5.4 yrs left)· nominal 20-yr term from priority
Inventors:Robert G. Matheny
A61L 27/54A61L 27/58A61L 27/34A61F 2210/0004A61L 2300/414A61F 2250/0067A61L 27/3633A61K 31/4418A61L 27/507A61L 27/3834A61L 2430/20A61F 2/06A61F 2/0095A61F 2/00
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Claims

Abstract

Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as poly(glycerol sebacate (PGS) or ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A cardiovascular prosthesis, consisting of:
 a sheet member consisting of an ECM-mimicking composition, said ECM-mimicking composition consisting of poly(glycerol sebacate) (PGS) and sirolimus.   
     
     
         2 . A cardiovascular prosthesis consisting of:
 a base structure consisting of acellular ECM from a mammalian tissue source, said sheet member further comprising a coating of an ECM-mimicking composition, said ECM-mimicking composition consisting of poly(glycerol sebacate) (PGS) and sirolimus.   
     
     
         3 . The prosthesis of  claim 2 , wherein said base structure comprises a sheet member. 
     
     
         4 . The prosthesis of  claim 2 , wherein said base structure comprises a tubular member.

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