Compositions and Methods for Reducing Oxidative Damage

Abstract

Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject.

1 - 20 . (canceled) 
     
     
         21 . A method of reducing or preventing oxidative damage to an eye lens of a subject, the method comprising contacting an eye lens of a subject with a composition comprising a polysaccharide antioxidant, wherein the composition has a refractive index of about 1.3 to about 1.4. 
     
     
         22 . The method according to  claim 21 , wherein contacting the eye lens of the subject comprises coating the eye lens with the composition. 
     
     
         23 . The method according to  claim 21 , wherein the composition is contacted with the eye lens during vitrectomy. 
     
     
         24 . The method according to  claim 21 , wherein the composition is contacted with the eye lens in an amount sufficient to prevent post-vitrectomy cataract formation. 
     
     
         25 . The method according to  claim 21 , wherein the polysaccharide antioxidant is trehalose. 
     
     
         26 . The method according to  claim 25 , wherein the refractive index of the composition is from about 1.33 to about 1.36. 
     
     
         27 . The method according to  claim 26 , wherein the composition has a surface energy of less than about 4 dyne/cm or greater than about 40 dyne/cm. 
     
     
         28 . The method according to  claim 27 , wherein the composition has an elasticity of about 50 N/m to about 1000 N/m. 
     
     
         29 . The method according to  claim 28 , wherein the composition has an osmolarity of about 281 mOsm to about 350 mOsm. 
     
     
         30 . The method according to  claim 25 , wherein the polysaccharide antioxidant is present in the composition at a concentration of about 0.001 wt % to about 10 wt %. 
     
     
         31 . The method according to  claim 30 , wherein the composition further comprises one or more of an emulsifier and a nonionic surfactant. 
     
     
         32 . The method according to  claim 21 , wherein the composition further comprises one or more of a poly(ethylene glycol) and a viscoelastic polymer. 
     
     
         33 . The method according to  claim 32 , further comprising polymerizing the composition. 
     
     
         34 . The method according to  claim 32 , wherein the poly(ethylene glycol) is poly(ethylene glycol) diacrylate. 
     
     
         35 . The method according to  claim 32 , wherein the viscoelastic polymer is selected from the group consisting of hyaluronic acid or a salt thereof, hydroxymethylpropyl cellulose, chondroitin sulfate, polyacrylamide, collagen, dextran, heparin, agarose, chitosan, and combinations thereof. 
     
     
         36 . The method according to  claim 32 , wherein the composition further comprises a photoinitiator. 
     
     
         37 . The method according to  claim 36 , wherein the photoinitiator is selected from the group consisting of 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone, eosin Y, triethanolamine, 1-vinyl-2-pyrrolidinone, and combinations thereof. 
     
     
         38 . A composition for reducing or preventing oxidative damage to an eye lens of a subject, the comprising a polysaccharide antioxidant, wherein the composition has a refractive index of about 1.3 to about 1.4.