Klebsiella pneumoniae strain that induces inflammation in the liver

Abstract

To identify a microorganism causing the development of primary sclerosing cholangitis associated with ulcerative colitis. A Klebsiella pneumoniae strain inducing inflammation in the liver.

1 . A  Klebsiella pneumoniae  strain inducing inflammation in the liver. 
     
     
         2 . The  Klebsiella pneumoniae  strain according to  claim 1 , Inducing a Th17 cell in the liver. 
     
     
         3 . The  Klebsiella pneumoniae  strain according to  claim 1 , having an ability to form a pore on the large intestinal epithelium. 
     
     
         4 . The  Klebsiella pneumoniae  strain according to  claim 1 , having a type 6 secretion system. 
     
     
         5 . The  Klebsiella pneumoniae  strain according to  claim 1 , derived from a patient suffering from both primary sclerosing cholangitis and ulcerative colitis. 
     
     
         6 . The  Klebsiella pneumoniae  strain according to  claim 1 , comprising a DNA consisting of a nucleotide sequence registered in the National Center for Biotechnology Information (NCBI) under Assembly Name: ASM385182v1. 
     
     
         7 . The  Klebsiella pneumoniae  strain according to  claim 1 , whose deposit number is NITE BP-02879. 
     
     
         8 . The  Klebsiella pneumoniae  strain according to  claim 1 , comprising a DNA consisting of a nucleotide sequence registered in the National Center for Biotechnology Information (NCBI) under Assembly Name: ASM386511v1. 
     
     
         9 . A  Proteus mirabilis  strain whose accession number is NITE BP-02923. 
     
     
         10 . An  Enterococcus gallinarum  strain whose accession number is NITE BP-02922. 
     
     
         11 . Use of a  Klebsiella pneumoniae  strain according to  claim 1  for prediction or diagnosis of the development of primary sclerosing cholangitis. 
     
     
         12 . Use of a  Klebsiella pneumoniae  strain according to  claim 1 , a  Proteus mirabilis  strain, and an  Enterococcus gallinarum  strain for prediction or diagnosis of the development of primary sclerosing cholangitis. 
     
     
         13 . The use for prediction or diagnosis of the development of primary sclerosing cholangitis according to  claim 12 , wherein the  Proteus mirabilis  strain is one whose accession number is NITE BP-02923; and the  Enterococcus gallinarum  strain is one whose accession number is NITE BP-02922. 
     
     
         14 . A method for producing a mouse model suffering from both primary sclerosing cholangitis and ulcerative colitis, the method comprising:
 administering a bacterial solution containing a  Klebsiella pneumoniae  strain according to  claim 1  to a mouse; and   administering 3,5-dicarbetoxy-1,4-dihydrocollidine to a mouse.