Fast diagnosis and personalized treatments for acne

Abstract

Methods of diagnosing and treating patients afflicted with acne, including diagnosing one as having acne if the individual possesses RT4, RT5, RT7, RT8, RT9, or RT10. Methods for treating acne include administering an effective amount of a drug specifically targeting RT4, RT5, RT7, RT8, RT9, or RT10, such as small molecules, antisense molecules, siRNAs, biologics, antibodies, phages, vaccines, or combination thereof.

1 - 46 . (canceled) 
     
     
         47 . A method of treating a skin condition in a subject in need thereof, the method comprising administering to the subject a composition comprising a  P. acnes  strain associated with healthy skin. 
     
     
         48 . The method of  claim 47 , wherein the skin condition is acne. 
     
     
         49 . The method of  claim 47 , wherein the composition is formulated in a topical cream or solution. 
     
     
         50 . The method of  claim 47 , wherein the composition is formulated in a cosmetic product. 
     
     
         51 . The method of  claim 47 , wherein the  P. acnes  strain associated with healthy skin does not have a ribotype comprising RT4, RT5, RT7, RT8, RT9 or RT10. 
     
     
         52 . The method of  claim 47 , wherein the  P. acnes  strain lacks a plasmid having SEQ ID NO: 31. 
     
     
         53 . The method of  claim 47 , wherein the  P. acnes  strain lacks a locus having SEQ ID NO: 29. 
     
     
         54 . The method of  claim 47 , wherein the  P. acnes  strain lacks a locus having SEQ ID NO: 30. 
     
     
         55 . The method of  claim 47 , wherein the  P. acnes  is characterized as associated with healthy skin based on its 16S rDNA. 
     
     
         56 . The method of  claim 47 , wherein treatment comprises prevention of acne. 
     
     
         57 . The method of  claim 47 , further comprising treating the subject with an active ingredient targeting a  P. acnes  associated with acne. 
     
     
         58 . The method of  claim 47 , wherein the  P. acnes  strain comprises CRISPR. 
     
     
         59 . A composition comprising a topical cream and a  P. acnes  strain associated with healthy skin. 
     
     
         60 . The composition of  claim 59 , wherein the  P. acnes  strain associated with healthy skin does not have a ribotype comprising RT4, RT5, RT7, RT8, RT9 or RT10. 
     
     
         61 . The composition of  claim 59 , wherein the  P. acnes  strain lacks a plasmid having SEQ ID NO: 31. 
     
     
         62 . The composition of  claim 59 , wherein the  P. acnes  strain lacks a locus having SEQ ID NO: 29. 
     
     
         63 . The composition of  claim 59 , wherein the  P. acnes  strain lacks a locus having SEQ ID NO: 30. 
     
     
         64 . The composition of  claim 59 , wherein the  P. acnes  is characterized as associated with healthy skin based on its 16S rDNA. 
     
     
         65 . The composition of  claim 59 , further comprising an active ingredient targeting a  P. acnes  associated with acne. 
     
     
         66 . The composition of  claim 59 , wherein the  P. acnes  comprises CRISPR.