US2019315774A1PendingUtilityA1
Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as par4 inhibitors
Est. expiryJul 14, 2036(~10 yrs left)· nominal 20-yr term from priority
Inventors:Xiaojun ZhangEldon Scott PriestleyOz Scott HalpernWen JiangSamuel Kaye ReznikJeremy Richter
C07D 493/04C07D 513/04A61P 7/02C07D 519/00A61K 31/497A61K 31/506C07D 515/14
56
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R 3 is a tricyclic heteroaryl group substituted with R 3a and zero to 2 R 3b ; and R 1 , R 2 , R 3a , R 3b , R 4 , and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A compound of Formula (I) to (VIII):
or a salt thereof; wherein:
R 1 is F, Cl, —OH, C 1-4 alkyl, C 1-4 fluoroalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-7 cycloalkyl, C 3-7 fluorocycloalkyl, C 1-4 alkoxy, C 1-4 fluoroalkoxy, C 2-4 hydroxyalkoxy, C 3-6 cycloalkoxy, (C 1-3 alkoxy)-(C 1-3 alkylene), (C 1-3 alkoxy)-(C 1-3 fluoroalkylene), (C 1-3 deuteroalkoxy)-(C 1-3 deuteroalkylene), (C 1-3 fluoroalkoxy)-(C 1-3 alkylene), (C 1-3 fluoroalkoxy)-(C 1-3 fluoroalkylene), —(CH 2 ) 1-30 (phenyl), —(CH 2 ) 1-3 NR a R a , —C(O)O(C 1-6 alkyl), —C(O)NR a R a , —C(O)NR b R b , —NH 2 , —NH(C 1-6 alkyl), —N(C 1-6 alkyl) 2 , azetidinyl, pyrrolidinyl, furanyl, pyranyl, piperidinyl, morpholinyl, piperazinyl, —S(O) 2 (C 1-3 alkyl), —S(O) 2 NR a R a , C 1-3 alkylthio, or C 1-3 fluoroalkylthio;
R 2 , at each occurrence, is independently H, F, Cl, Br, —OH, —CN, C 1-4 alkyl, C 1-4 fluoroalkyl, C 1-4 hydroxyalkyl, C 1-3 aminoalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-7 cycloalkyl, C 3-7 fluorocycloalkyl, C 1-6 alkoxy, C 1-3 fluoroalkoxy, C 1-3 alkylthio, C 1-3 fluoroalkylthio, (C 1-3 alkoxy)-(C 1-3 alkylene), (C 1-3 fluoroalkoxy)-(C 1-3 alkylene), —C(O)NH 2 , —C(O)NH(C 1-6 alkyl), —C(O)N(C 1-6 alkyl) 2 , —C(O)NR b R b , —CH(OH)(C 3-6 cycloalkyl), —CH(OH)(phenyl), CH(OH)(pyridyl), —S(O) 2 (C 1-3 alkyl), —S(O) 2 NR a R a , or a cyclic group selected from phenyl, 5- to 6-membered heteroaryl, and 5- to 7-membered heterocycle, wherein said cyclic group is substituted with zero to 5 substituents independently selected from F, Cl, hydroxy, C 1-3 alkyl, C 1-3 alkoxy, cyclopropyl, and —CN;
R 3 is:
(i) X 1 is N and X 2 is S, O, or NH;
(ii) X 1 is O and X 2 is CH or N;
(iii) X 1 is NH and X 2 is CH; or
(iv) X 1 is CH and X 2 is S or NH;
and the dashed lines represent the variable position of a double bond to maintain aromaticity,
each R 3 is substituted with R 3a and zero to 3 R 3b ;
R 3a is:
(i) H, C 1-6 hydroxyalkyl, C 1-6 hydroxyfluoroalkyl, —C(O)O(C 1-6 alkyl), —CR a R a NHC(O)(C 1-6 alkyl), —CR a R a NHC(O)(C 1-6 fluoroalkyl), —CR a R a NHC(O)O(C 1-6 alkyl), —CR a R a NHC(O)O(CH 2 ) 1-3 (C 1-3 alkoxy), —CR a R a NHC(O)O(C 1-4 fluoroalkyl), —CR a R a N a S(O) 2 (C 1-3 alkyl), CR a R a N a S(O) 2 (C 1-3 fluoroalkyl), —CR a R a OP(O)(OH) 2 , —CR a R a NHC(O)R x , —CR a R a NHC(O)OR x , —CR a R a NHC(O)CH 2 R x , —CR a R a NHC(O)OCH 2 R x , —CR a R a OC(O)NHR x , —CR a R a NHC(O)NHR x , —CR a R a OR x , or —CR a R a OC(O)R x ;
(ii) —CH(OH)CR h R i R j wherein R h and R i are independently H, F, C 1-4 alkyl, C 1-4 fluoroalkyl, C 1-3 alkoxy, or C 1-3 fluoroalkoxy, or taken together with the carbon atom to which they are attached, form C 3-8 cycloalkyl or 4- to 7-membered heterocyclyl ring; and R j is H, C 1-6 alkyl, C 1-5 fluoroalkyl, (C 1-3 alkoxy)-(C 1-3 alkyl), C 3-8 cycloalkyl, C 3-8 heterocyclyl, aryl, or heteroaryl;
R x is C 3-6 cycloalkyl, phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, benzo[d]oxazolyl, benzo[d]thiazolyl, pyrrolopyridinyl, tetrahydroisoquinolinyl, tetrahydrofuranyl, tetrahydropyranyl, morpholinyl, imidazopyridinyl, or oxo-dihydrobenzo[d]oxazolyl, each substituted with zero to two substituents independently selected from F, Cl, Br, —CN, —OH, —CH 3 , —CF 3 , C 1-3 alkoxy, C 1-3 fluoroalkyl, C 1-6 hydroxyalkyl, C 1-6 hydroxyalkoxy, C 1-6 hydroxy-fluoroalkoxy, phenoxy, —NR a R a , —C(O)NR a R a , —C(O)NH(C 1-6 alkyl), —C(O)N(C 1-6 alkyl) 2 , —C(O)NR b R b , —C(O)NR a (C 1-6 hydroxyalkyl), —C(O)O(C 1-6 alkyl), —C(O)OC 1-4 alkyl, —C(O)(morpholinyl), —S(O) 2 NR a R a , —CH(OH)CH 2 OH, —CH═CH 2 , —NHC(O)CH 3 , —OCH 2 CH 2 N(CH 3 ) 2 , —OCH 2 CH 2 OH, —OCH 2 CH(Me)OH, isoxazolyl, phenoxy, phenyl, pyrrolidinyl, thiophenyl, and methyl triazolyl;
R 3b , at each occurrence, is independently H, F, Cl, Br, —CN, C 1-3 alkyl, C 1-3 fluoroalkyl, C 1-3 hydroxyalkyl, —OCHF 2 , C 3-6 cycloalkyl, C 3-6 fluorocycloalkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-3 alkoxy, C 1-3 alkylthio, or C 1-3 fluoroalkoxy;
R 4 is H, F, Cl, or —CH 3 ;
R a , at each occurrence, is independently H, C 1-4 alkyl, or C 1-4 fluoroalkyl;
two R b along with the nitrogen atom to which they are attached form a 4- to 7-membered heterocyclo ring having 1 to 2 nitrogen atoms and 0-1 oxygen or sulfur atoms; and
n is zero, 1, or 2.
2 . The compound according to claim 1 having the structure of Formula (I) or Formula (II):
or a salt thereof, wherein:
R 3 is:
X 1 is N and X 2 is S or O; or
X 1 is O and X 2 is CH; and
each R 3 is substituted with R 3a and zero to 3 R 3b .
3 . The compound according to claim 2 having the structure of Formula (Ia) or Formula (IIa): —
or a salt thereof, wherein:
R 1 is —CH 3 , —OCH 3 , —OCH 2 CH 3 , or —OCHF 2 ;
R 2 is F, Cl, —CN, —CH 3 , —CH 2 F, —CHF 2 , —CH 2 OH, —CH(CH 3 )OH, or —CH═CH 2 ;
R 3a is H, —CH 2 OH, —CH(CH 3 )OH, —CH 2 CH(CH 3 )OH, —CH(OH)C(CH 3 ) 3 , —CH(OH)(trifluoromethyl cyclopropyl), —CH(OH)(trifluoromethyl cyclobutyl), —CH(OH)(methyl cyclohexyl), —CH 2 NHC(O)CH 3 , —CH 2 NHC(O)CF 3 , —CH 2 NHC(O)CH 2 (phenyl), —CH 2 NHC(O)(morpholinyl), —CH 2 NHC(O)OCH 3 , —CH 2 NHC(O)NH(cyclopropyl), —CH 2 NHC(O)NH(phenyl), —CH 2 NHC(O)OCH 3 , —CH 2 NHC(O)OCH 2 CH 3 , —CH 2 NHC(O)OC(CH 3 ) 3 , —CH 2 NHC(O)OCH 2 CH(CH 3 ) 2 , —CH 2 NHC(O)OCH 2 C(CH 3 ) 3 , —CH 2 NHC(O)OCH 2 CH 2 F, —CH 2 NHC(O)OCH 2 CF 3 , —CH 2 NHC(O)OCH 2 CH 2 OCH 3 , —CH 2 NHS(O) 2 CH 3 , —CH 2 O(methyl pyrimidinyl), —CH 2 OC(O)(dimethylaminopyridinyl), —CH 2 OP(O)(OH) 2 , —C(O)OCH 3 , —CH 2 NHC(O)OR x , —CH 2 NHC(O)OCH 2 R x , or —CH 2 OC(O)NHR x ;
R x is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, benzo[d]oxazolyl, benzo[d]thiazolyl, oxoisoindolinyl, pyrrolopyridinyl, tetrahydroisoquinolinyl, tetrahydrofuranyl, tetrahydropyranyl, imidazopyridinyl, or oxo-dihydrobenzo[d]oxazolyl, each substituted with zero to two substituents independently selected from F, Cl, Br, —CN, —OH, —CH 3 , —CF 3 , —CH 2 CH 2 OH, C 1-2 alkoxy, phenoxy, —NR a R a , —C(O)NR a R a , —C(O)OCH 3 , —C(O)OC(CH 3 ) 3 , —C(O)(morpholinyl), —CH(OH)CH 2 OH, —OCH 2 CH 2 OH, —OCH 2 CF 2 OH, —OCH 2 CH(CH 3 )OH, —CH═CH 2 , —NHC(O)CH 3 , —OCH 2 CH 2 N(CH 3 ) 2 , isoxazolyl, phenoxy, phenyl, pyrrolidinyl, thiophenyl, and methyl triazolyl; and
R 3b is H, F, Cl, —CH 3 , or —CHF 2 .
4 . The compound according to claim 3 or a salt thereof, wherein said compound of Formula (Ia) is selected from:
where R 3c is H or F.
5 . The compound according to claim 4 or a salt thereof, wherein R x is:
(i) pyridazinyl, benzo[d]oxazolyl, benzo[d]thiazolyl, pyrrolopyridinyl, tetrahydroisoquinolinyl, methyl imidazopyridinyl, or oxo-dihydrobenzo[d]oxazolyl;
(ii) phenyl substituted with zero to 1 substituent selected from —CN and —C(O)(morpholinyl);
(iii) pyridinyl substituted with zero to two substituents independently selected from F, Cl, Br, —CN, —OH, —CH 3 , —CF 3 , C 1-2 alkoxy, phenoxy, —NH 2 , —N(CH 3 ) 2 , —C(O)NH 2 , —C(O)OC(CH 3 ) 3 , —C(O)OCH 3 , —CH(OH)CH 2 OH, —CH═CH 2 , —NHC(O)CH 3 , —OCH 2 CH 2 N(CH 3 ) 2 , phenyl, pyrrolidinyl, thiophenyl, and methyl triazolyl; or
(iv) pyrimidinyl substituted with C 1 or —CH 3 .
6 . The compound according to claim 1 or a salt thereof, wherein said compound is selected from:
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (1);
(S)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (2);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′: 3,4]benzo [1,2-d]thiazol-7-yl)methyl (2-hydroxypyridin-4-yl)carbamate (3);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (4);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (5);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′: 3,4]benzo[1,2-d]thiazol-7-yl)methyl pyridin-3-yl carbonate (6);
(R)-(6-chloro-8-(2-methoxy-7-methylquinoxalin-5-yl)-2,3-dihydro-[1,4]dioxino[2,3-e]benzofuran-3-yl)methyl (6-methylpyridin-3-yl)carbamate (7);
(R)-(6-chloro-8-(2-methoxy-7-methylquinoxalin-5-yl)-2,3-dihydro-[1,4] dioxino [2,3-e]benzofuran-3-yl)methyl (2-methylpyridin-4-yl)carbamate (8);
(R)-(6-chloro-8-(2-methoxy-7-methylquinoxalin-5-yl)-2,3-dihydro-[1,4] dioxino [2,3-e]benzofuran-3-yl) methyl (6-methoxypyridin-3-yl)carbamate (9);
(R)-(6-chloro-8-(2-methoxy-7-methylquinoxalin-5-yl)-2,3-dihydro-[1,4] dioxino [2,3-e]benzofuran-3-yl)methyl pyridin-3-ylcarbamate (10);
(R)-(8-(2-methoxy-7-methylquinoxalin-5-yl)-2,3-dihydro-[1,4]dioxino[2,3-e]benzofuran-3-yl)methyl (6-methylpyridin-3-yl)carbamate (11);
(R)-(8-(2-methoxy-7-methylquinoxalin-5-yl)-2,3-dihydro-[1,4] dioxino [2,3-e] benzofuran-3-yl) methyl (2-methylpyridin-4-yl)carbamate (12);
(R)-(8-(2-methoxy-7-methylquinoxalin-5-yl)-2,3-dihydro-[1,4] dioxino [2,3-e] benzofuran-3-yl)methyl (6-methoxypyridin-3-yl) carbamate (13);
(R)-(8-(2-methoxy-7-methylquinoxalin-5-yl)-6-methyl-2,3-dihydro-[1,4] dioxino [2,3-e]benzofuran-3-yl)methyl (6-methylpyridin-3-yl)carbamate (14);
(R)-(8-(2-methoxy-7-methylquinoxalin-5-yl)-6-methyl-2,3-dihydro-[1,4] dioxino [2,3-e]benzofuran-3-yl)methyl (2-methylpyridin-4-yl)carbamate (15);
(R)-(8-(2-methoxy-7-methylquinoxalin-5-yl)-6-methyl-2,3-dihydro-[1,4] dioxino [2,3-e]benzofuran-3-yl)methyl (6-methoxypyridin-3-yl)carbamate (16);
(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (17);
(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (18);
(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl (6-methylpyridin-3-yl)carbamate (19);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl (6-methylpyridin-3-yl)carbamate (20); tert-butyl ((2-(2-(difluoromethoxy)-7-methylquinoxalin-5-yl)-4-fluoro-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl)carbamate (21);
(2-(2-(difluoromethoxy)-7-methylquinoxalin-5-yl)-4-fluoro-7, 8-dihydro-[1,4]dioxino[2′,3′:3,4] benzo[1,2-d]thiazol-8-yl)methanol (22); tert-butyl ((2-(2-(difluoromethoxy)-7-methylquinoxalin-5-yl)-4-fluoro-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-8-yl)methyl)carbamate (23);
(4-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo[1,2-d]thiazol-8-yl)methyl phenylcarbamate (24);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (5-chloropyridin-3-yl)carbamate (25);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d] thiazol-7-yl)methyl phenylcarbamate (26);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl (3-cyanophenyl)carbamate (27);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (5-fluoropyridin-3-yl)carbamate (28);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-fluoropyridin-3-yl)carbamate (29);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl pyridin-4-ylcarbamate (30);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (31);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d] thiazol-7-yl)methyl (6-chloropyridin-3-yl)carbamate (32);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl (2-methylpyridin-4-yl)carbamate (33);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl pyridazin-4-ylcarbamate (34);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4]dioxino [2′,3:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-cyanopyridin-3-yl)carbamate (35);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4]dioxino [2′,3:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methoxypyridin-4-yl)carbamate (36);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (5-cyanopyridin-3-yl)carbamate (37);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-cyanopyridin-3-yl)carbamate (38);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d] thiazol-7-yl)methyl benzo[d]thiazol-5-ylcarbamate (39);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl benzo[d]thiazol-6-ylcarbamate (40);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-fluoropyridin-3-yl)carbamate (41);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (5-fluoropyridin-3-yl)carbamate (42);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (5-methoxypyridin-3-yl)carbamate (43);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydr-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methylpyridin-4-yl)carbamate (44);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methoxypyridin-4-yl)carbamate (45);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (3-cyanophenyl)carbamate (46);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-chloropyridin-3-yl) carbamate (47);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl pyridin-4-ylcarbamate (48);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydr-[1,4]dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl benzo[d]thiazol-5-ylcarbamate (49);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl benzo[d]thiazol-6-ylcarbamate (50);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (5-cyanopyridin-3-yl)carbamate (51);
(R)-(2-(2,7-dimethylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-(dimethylamino) pyridin-3-yl) carbamate (52);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-(thiophen-2-yl) pyridin-3-yl)carbamate (53);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (3-methyl-3H-imidazo [4,5-b]pyridin-6-yl)carbamate (54);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-(3-methyl-1H-1,2,4-triazol-1-yl)pyridin-3-yl)carbamate (55);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methylpyridin-3-yl)carbamate (56);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (5-methylpyridin-3-yl)carbamate (57);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl (2-chloropyrimidin-5-yl)carbamate (58);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-chloropyrimidin-5-yl)carbamate (59);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (5,6-dimethylpyridin-3-yl) carbamate (60);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-fluoro-5-methylpyridin-3-yl)carbamate (61);
(R)-(4-chloro-2-(2,7-dimethylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methylpyridin-3-yl) carbamate (62);
(R)-(4-chloro-2-(2,7-dimethylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (5-methylpyridin-3-yl)carbamate (63);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (6-fluoro-5-methylpyridin-3-yl)carbamate (64); (R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4]dioxino [2′,3′:3,4]benzo[1,2-d] thiazol-7-yl)methyl (6-(dimethylamino)pyridin-3-yl)carbamate (65);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d] thiazol-7-yl)methyl (2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)carbamate (66);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)carbamate (67);
(R)-(4-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (68);
(R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d] thiazol-7-yl)methyl (6-(3-methyl-1H-1,2,4-triazol-1-yl)pyridin-3-yl)carbamate (69);
(R)-(4-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (70);
(R)-(4-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl (6-fluoropyridin-3-yl)carbamate (71);
(R)-(4-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl (3-cyanophenyl)carbamate (72);
(R)-(4-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl pyridin-4-ylcarbamate (73);
(4-(difluoromethyl)-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methylpyridin-4-yl) carbamate (74);
(R)-(4-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methylpyridin-4-yl)carbamate (75);
(R)-(4-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methylpyridin-3-yl)carbamate (76);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (5-carbamoylpyridin-3-yl)carbamate (77);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)carbamate (78);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (79);
(R)-(4-(difluoromethyl)-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxin o[2′,3′:3,4]benzo[1,2-d] thiazol-7-yl)methyl (6-methylpyridin-3-yl)carbamate (80);
(R)-(4-(difluoromethyl)-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxin o[2′,3′:3,4]benzo[1,2-d] thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (81);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl benzo[d]oxazol-5-ylcarbamate (82);
(R)-(4-fluoro-2-(7-(hy droxymethyl)-2-methoxy quinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl pyridin-3-ylcarbamate (83);
(R)-(2-(7-(difluoromethyl)-2-methoxyquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxin o[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methylpyridin-4-yl)carbamate (84);
(R)-(4-fluoro-2-(7-(hy droxymethyl)-2-methoxy quinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl (2-methylpyridin-4-yl)carbamate (85);
(2-(2-methoxy-7-vinylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (86);
(2-(7-(hydroxymethyl)-2-methoxyquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (87);
(2-(7-(1-hydroxyethyl)-2-methoxyquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (88);
(2-(2-methoxy-7-vinylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (89);
(2-(7-(hydroxymethyl)-2-methoxyquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (90);
(R)-(2-(7-cyano-2-methoxyquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4]dioxino[2′,3′: 3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methylpyridin-3-yl)carbamate (91);
(R)-(2-(7-cyano-2-methoxyquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4]dioxino[2′,3′: 3,4]benzo[1,2-d] thiazol-7-yl)methyl (2-methylpyridin-4-yl)carbamate (92);
(R)-(2-(7-cyano-2-methoxyquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4]dioxino[2′,3′: 3,4]benzo[1,2-d] thiazol-7-yl)methyl pyridin-3-ylcarbamate (93);
(R)-(2-(7-cyano-2-methoxyquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (94);
(2-(7-chloro-2-methoxyquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benz o[1,2-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (95);
(2-(7-chloro-2-methoxyquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-fluoropyridin-3-yl)carbamate (96);
(2-(7-chloro-2-methoxyquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo [1,2-d]thiazol-7-yl)methyl (6-methylpyridin-3-yl)carbamate (97);
(R)-(2-(7-(hydroxymethyl)-2-methoxyquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (98);
(R)-(2-(7-(hydroxymethyl)-2-methoxyquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methylpyridin-4-yl)carbamate (99);
(R)-(2-(7-(hydroxymethyl)-2-methoxyquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-methylpyridin-3-yl)carbamate (100);
(R)-(2-(7-(hydroxymethyl)-2-methoxyquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (101);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo[1,2-d] thiazol-7-yl)methyl (6-methylpyridin-3-yl)carbamate (102);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl (2-methylpyrimidin-5-yl)carbamate (103);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl (6-methoxypyridin-3-yl)carbamate (104);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (6-cyanopyridin-3-yl)carbamate (105);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo [1,2-d]thiazol-7-yl)methyl (2-oxo-2,3-dihydrobenzo [d]oxazol-6-yl)carbamate (106);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl 1H-pyrrolo[2,3-b] pyridin-5-ylcarbamate (107);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo[1,2-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (108);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo[1,2-d] thiazol-7-yl)methyl (6-bromopyridin-3-yl)carbamate (109);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl) methyl (6-vinylpyridin-3-yl)carbamate 110);
((R)-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (6-((S)-1,2-dihydroxyethyl)pyridin-3-yl)carbamate (111);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo [1,2-d]thiazol-7-yl)methyl (6-fluoropyridin-3-yl)carbamate (112);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4]dioxino[2′,3′:3,4] benzo[1,2-d]thiazol-7-yl)methyl (5-cyanopyridin-3-yl)carbamate (113);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo [1,2-d]thiazol-7-yl)methyl (4-(morpholine-4-carbonyl)phenyl)carbamate (114);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (6-chloropyridin-3-yl)carbamate (115);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (6-(dimethylamino)pyridin-3-yl)carbamate (116);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (2-phenylpyridin-4-yl)carbamate (117);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (2-fluoropyridin-4-yl)carbamate (118);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (5,6-dimethylpyridin-3-yl)carbamate (119);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (6-methylpyridin-3-yl)carbamate (120);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4]benzo [1,2-d]thiazol-7-yl)methyl (6-phenoxypyridin-3-yl)carbamate (121);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (6-fluoro-5-methylpyridin-3-yl)carbamate (122);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (6-hydroxypyridin-3-yl)carbamate (123);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (5-methylpyridin-3-yl)carbamate (124);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (6-phenylpyridin-3-yl)carbamate (125);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (5-phenylpyridin-3-yl)carbamate (126);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4]dioxino[2′,3′:3,4] benzo[1,2-d]thiazol-7-yl)methyl (6-(thiophen-2-yl)pyridin-3-yl) carbamate (127);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (6-(2-(dimethylamino)ethoxy) pyridin-3-yl)carbamate (128);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (3-methyl-3H-imidazo [4,5-b] pyridin-6-yl)carbamate (129);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (6-(3-methyl-1H-1,2,4-triazol-1-yl)pyridin-3-yl)carbamate (130);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (6-(trifluoromethyl)pyridin-3-yl)carbamate (131);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (5-chloropyridin-3-yl)carbamate (132);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (6-ethoxypyridin-3-yl)carbamate (133); methyl 4-((((2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methoxy)carbonyl)amino) picolinate (134);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (5-methylpyridin-3-yl)carbamate (135); tert-butyl 4-(5-((((2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino[2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methoxy)carbonyl)amino)pyridin-2-yl) piperazine-1-carboxylate (136);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (6-(pyrrolidin-1l-yl) pyridin-3-yl)carbamate (137); methyl 5-((((2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methoxy)carbonyl) amino)nicotinate (138); tert-butyl 3-((((2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methoxy)carbonyl) amino)-7, 8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (139);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (6-acetamidopyridin-3-yl)carbamate (140);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino [2′,3′: 3,4] benzo [1,2-d]thiazol-7-yl)methyl (6-aminopyridin-3-yl)carbamate (141);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7, 8-dihydro-[1,4] dioxino[2′,3′: 3,4]benzo[1,2-d]thiazol-7-yl)methyl 1H-pyrrolo[2,3-b]pyridin-5-ylcarbamate (142);
6-(2-(methoxymethyl)-7-methylquinoxalin-5-yl)-[1,3] dioxolo[4′,5′:4,5]benzo[1,2-d]thiazole (143);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl(2-methylpyrimidin-5-yl)carbamate (144);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl) carbamate (145);
(S)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (146);
(S)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl(6-methylpyridin-3-yl)carbamate (147);
(4-chloro-2-(7-(hydroxymethyl)-2-methoxy quinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl(6-methylpyridin-3-yl)carbamate (148);
(S)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (149);
(S)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl(2-methylpyrimidin-5-yl)carbamate (150);
(S)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl) carbamate (151);
(S)-(2-(2-ethoxy-7-methylquinoxalin-5-yl)-5-fluoro-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (152);
(R)-(2-(2-ethoxy-7-methylquinoxalin-5-yl)-5-fluoro-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl(2-methylpyrimidin-5-yl)carbamate (153);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (5-cyanopyridin-3-yl)carbamate (154);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (2-(2-hydroxyethyl)pyrimidin-5-yl)carbamate (155); (S)-methyl 2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazole-7-carboxylate (156);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (157);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl pyridazin-4-ylcarbamate (158);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (6-methylpyridin-3-yl)carbamate (159);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (2-methylpyridin-4-yl)carbamate (160);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (5-fluoropyridin-3-yl)carbamate (161);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (3-cyanophenyl)carbamate (162);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (2-methoxypyridin-4-yl)carbamate (163);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (6-methoxypyridin-3-yl)carbamate (164);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (6-(2-hydroxyethoxy)pyridin-3-yl)carbamate (165);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (6-(2,2-difluoro-3-hydroxypropoxy)pyridin-3-yl)carbamate (166);
(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (167);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl(5-methoxypyridin-3-yl)carbamate (168);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (4-(morpholine-4-carbonyl) phenyl)carbamate (169);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (6-fluoropyridin-3-yl)carbamate (170);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (171);
(S)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methanol (172);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (2-(2-hydroxyethoxy)pyrimidin-5-yl)carbamate (173);
(S)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (174);
(S)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (175);
(S)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (3-cyanophenyl)carbamate (176);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (2-methoxypyrimidin-5-yl)carbamate (177);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl(3-oxoisoindolin-5-yl)carbamate (178);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (3-cyano-5-fluorophenyl)carbamate (179);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (3-carbamoylphenyl)carbamate (180);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5, 4-d]thiazol-7-yl)methanol (181);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5, 4-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (182);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (183);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5, 4-d]thiazol-7-yl)methyl (3-cyanophenyl)carbamate (184);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5, 4-d]thiazol-7-yl)methyl pyrimidin-5-ylcarbamate (185);
2-(2-methoxy-7-methylquinoxalin-5-yl)-7,7-dimethyl-7, 8-dihydrobenzofuro [5,4-d]thiazol e (186);
(S)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methanol (187);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methanol (188);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-8-methyl-7, 8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (189);
(S)-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)ethanol (190); Methyl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (191); Phenyl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methy 1)carbamate (192); benzyl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methy 1) carbamate (193);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (194);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (195);
(R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl(3-cyanophenyl) carbamate (196);
ethyl((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl) methyl)carbamate (197); Isobutyl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methy 1)carbamate (198);
cis-5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-8-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methanol (199);
5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,7-dimethyl-7,8-dihydrobenzofuro[5,4-d]thiazole (200);
trans-5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-8-methyl-7,8-dihydrobenzofuro[5, 4-d]thiazol-7-yl)methanol (201); (S)-tert-butyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl)carbamate (202);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (3-(dimethylcarbamoyl)phenyl)carbamate (203);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (4-(dimethylcarbamoyl)phenyl)carbamate (204);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (5-carbamoylpyridin-3-yl)carbamate (205);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-8, 8-dimethyl-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (206);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (4-(oxazol-2-yl)phenyl)carbamate (207);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl (4-(methylcarbamoyl)phenyl)carbamate (208);
(S)—N-((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)acetamide (209); (S)-methyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d] thiazol-7-yl)methyl)carbamate (210); (S)-benzyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d] thiazol-7-yl)methyl) carbamate (211); (S)-phenyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d] thiazol-7-yl)methyl)carbamate (212); (S)-p-tolyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl) carbamate (213); (S)-4-chlorophenyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (214);
(S)-2,2,2-trifluoro-N-((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)acetamide (215); (S)-4-methoxyphenyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d] thiazol-7-yl)methyl)carbamate (216);
(R)—N-((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)-2-phenylacetamide (217); (R)-methyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl) carbamate (218);
(R)—N-((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)acetamide (219); (R)-phenyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d] thiazol-7-yl)methyl) carbamate (220); (R)-benzyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d] thiazol-7-yl)methyl)carbamate (221);
(R)-2,2,2-trifluoro-N-((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl)acetamide (222); (R)-tert-butyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (223); (S)-isobutyl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methy 1) carbamate (224); (S)-benzyl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methy 1)carbamate (225); (S)-methyl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methy 1) carbamate (226); (S)-tetrahydro-2H-pyran-4-yl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methy 1)carbamate (227);
(S)—N-((2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro[5,4-d]thiazol-7-yl) methyl) methanesulfonamide (228); (Tetrahydrofuran-3-yl)methyl (((S)-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl)carbamate (229); (R)-tetrahydrofuran-3-yl (((S)-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (230); (S)-3-cyanobenzyl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methy 1) carbamate (231); (S)-pyridin-3-ylmethyl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methy 1)carbamate (232); (S)-pyridin-4-ylmethyl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methy 1) carbamate (233); Tetrahydro-2H-pyran-3-yl (((S)-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (234); (Tetrahydro-2H-pyran-2-yl)methyl (((S)-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (235); (S)-tetrahydrofuran-3-yl (((S)-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (236);
(S)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl dihydrogen phosphate (237); ((7S,8S)-5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-8-methyl-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (238);
((7R,8R)-5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-8-methyl-7, 8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (239); (S)-methyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl)carbamate (240); (S)-isobutyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7, 8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl) carbamate (241); (S)-tert-butyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl)carbamate (242);
(R)-1-((S)-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)ethanol(243); (S)-tert-butyl ((2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methy 1)carbamate (244); (S)-tetrahydro-2H-pyran-4-yl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl)carbamate (245); (S)-isobutyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (246); (S)-2-fluoroethyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (247);
(S)-1-((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl)-3-phenylurea (248); (S)-2,2,2-trifluoroethyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (249); (S)-2-methoxyethyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (250);
(R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-methyl-7,8-dihydrobenzofuro[5, 4-d]thiazol-7-yl)methyl (2-(2-hydroxyethoxy)pyrimidin-5-yl)carbamate (251);
((7R,8R)-5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-8-methyl-7, 8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl (2-(2-hydroxyethoxy)pyrimidin-5-yl)carbamate (252);
((7S,8S)-2-(7-chloro-2-methoxyquinoxalin-5-yl)-5-fluoro-8-methyl-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl) methanol (253);
8-((7 S, 8S)-5-fluoro-7-(hydroxymethyl)-8-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-2-yl)-3-methoxyquinoxaline-6-carbonitrile (254); Methyl (((7S,8S)-5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-8-methyl-7,8-dihydrobenzofuro[5,4-d] thiazol-7-yl)methyl)carbamate (255); Isobutyl (((7S,8S)-5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-8-methyl-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl) carbamate (256);
(S)-1-cyclopropyl-3-((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl)urea (257);
(S)—N-((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl) morpholine-4-carboxamide (258);
((7S,8S)-2-(2-ethoxy-7-methylquinoxalin-5-yl)-5-fluoro-8-methyl-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (259); (S)-ethyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl) methyl)carbamate (260); (S)-neopentyl ((5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl)carbamate (261);
1-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo[1,2-d]thiazol-4-yl)-2,2-dimethylpropan-1-ol (262);
1-(7-(2-methoxy-7-methylquinoxalin-5-yl)-[1,3]dioxolo [4′,5′:3,4]benzo[1,2-d]thiazol-5-yl)-2,2-dimethylpropan-1-ol (263);
1-(2-(2-methoxy-7-methylquinoxalin-5-yl)-8,9-dihydro-7H-[1,4] dioxepino[2′,3′: 3,4]benzo[1,2-d]thiazol-4-yl)-2,2-dimethylpropan-1-ol (264);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo [1,2-d]thiazol-4-yl)(1-(trifluoromethyl)cyclobutyl)methanol (265);
(R)-(2-(6-chloro-3-methoxyquinolin-8-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (266);
(R)-(2-(6-chloro-3-methoxyquinolin-8-yl)-5-fluoro-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl) methyl (2-methylpyrimidin-5-yl)carbamate (267);
(R)-(2-(3-methoxy-6-methylquinolin-8-yl)-7, 8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (268);
(R)-(5-fluoro-2-(3-methoxy-6-methylquinolin-8-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (269);
(R)-(2-(6-chloro-3-ethoxyquinolin-8-yl)-5-fluoro-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (270);
(R)-(2-(6-chloro-3-ethoxyquinolin-8-yl)-7, 8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo [1,2-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (271);
(R)-(2-(6-chloro-3-(difluoromethoxy)quinolin-8-yl)-7,8-dihydro-[1,4] dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (272);
(R)-(2-(6-chloro-3-(difluoromethoxy)quinolin-8-yl)-5-fluoro-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (273);
1-(2-(6-chloro-3-methoxyquinolin-8-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-4-yl)-2,2-dimethylpropan-1-ol (274);
(R)-(2-(6-(difluoromethyl)-3-methoxyquinolin-8-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (275);
(R)-(2-(6-(fluoromethyl)-3-methoxyquinolin-8-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (276);
1-(2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo[1,2-d]thiazol-4-yl)-2,2-dimethylpropan-1-ol (277);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazol-4-yl)(1-methylcyclohexyl)methanol (278);
(2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo [1,2-d]thiazol-4-yl)(1-(trifluoromethyl)cyclopropyl)methanol (279);
(R)-(5-fluoro-2-(6-fluoro-3-methoxyquinolin-8-yl)-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl)carbamate (280);
(R)-(2-(6-fluoro-3-methoxyquinolin-8-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4] benzo [1,2-d]thiazol-7-yl)methyl (2-methylpyrimidin-5-yl) carbamate (281);
(R)-(2-(6-chloro-3-methoxyquinolin-8-yl)-5-fluoro-7,8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methanol (282);
(R)-(2-(6-chloro-3-methoxyquinolin-8-yl)-5-fluoro-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl pyridin-3-ylcarbamate (283);
(R)-(2-(6-chloro-3-methoxyquinolin-8-yl)-5-fluoro-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (3-carbamoylphenyl)carbamate (284);
(S)-(2-(6-chloro-3-methoxyquinolin-8-yl)-5-fluoro-7-methyl-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (285);
(R)-(2-(6-chloro-3-methoxyquinolin-8-yl)-5-fluoro-7-methyl-7, 8-dihydrobenzofuro [5,4-d]thiazol-7-yl)methyl (2-(2-hydroxyethoxy)pyrimidin-5-yl)carbamate (286);
(R)-(2-(6-chloro-3-methoxyquinolin-8-yl)-7,8-dihydro-[1,4]dioxino [2′,3′:3,4] benzo[1,2-d]thiazol-7-yl)methyl (2-(2-hydroxyethoxy)pyrimidin-5-yl) carbamate (287); ((R)-2-(6-chloro-3-methoxyquinolin-8-yl)-7,8-dihydro-[1,4]dioxino [2′,3′: 3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-((S)-2-hydroxypropoxy)pyrimidin-5-yl) carbamate (288); ((R)-2-(6-chloro-3-methoxyquinolin-8-yl)-7,8-dihydro-[1,4]dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methyl (2-((R)-2-hydroxypropoxy)pyrimidin-5-yl)carbamate (289);
((7S,8S)-2-(6-chloro-3-methoxyquinolin-8-yl)-5-fluoro-8-methyl-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methanol (290);
(S)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7, 8-dihydro-[1,4] dioxino [2′,3′:3,4]benzo[1,2-d]thiazol-7-yl)methanol (291); and
(S)-5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7-(((2-methylpyrimidin-5-yl)oxy)methyl)-7,8-dihydro-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]thiazole (292).
7 . A pharmaceutical composition, which comprises a pharmaceutically acceptable carrier and a compound according to claim 1 or a pharmaceutically acceptable salt thereof, alone or in combination with another therapeutic agent.
8 . A method for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder, which comprises the steps of administering to a patient in need thereof a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart or in the peripheral circulation.
9 . The method according to claim 8 wherein the thromboembolic disorder is selected from the group consisting of unstable angina, an acute coronary syndrome, atrial fibrillation, myocardial infarction, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from medical implants, devices, and procedures in which blood is exposed to an artificial surface that promotes thrombosis.
10 . A method of inhibiting or preventing platelet aggregation, which comprises the step of administering to a subject in need thereof a therapeutically effective amount of a compound according to claim 1 or a salt thereof.Join the waitlist — get patent alerts
Track US2019315774A1 — get alerts on status changes and closely related new filings.
We store only your email — no account needed. See our privacy policy.