Treatment of hormonal disorders of growth

Abstract

The present invention refers to a GPR101 inhibitor, antagonist or inverse agonist or inverse agonist for use in preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism. Further, the present invention provides a GPR101 agonist for use in preventive and/or therapeutic treatment of disorders selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion wherein to a subject GPR101 agonist is administered.

1 . A non-human transgenic animal, comprising an expressed transgene encoding GPR101. 
     
     
         2 . The non-human transgenic animal according to  claim 1 , wherein the transgene comprises the nucleic acid sequence shown in SEQ ID NO: 1, or encodes a protein having the amino acid sequence shown in SEQ ID NO: 2. 
     
     
         3 . The non-human transgenic animal according to  claim 1 , wherein the transgenic animal is a transgenic mammal. 
     
     
         4 . The non-human transgenic animal according to  claim 1 , wherein the animal is a chicken    
     
     
         5 . The non-human transgenic animal according to  claim 1 , wherein the animal is a cow or a pig. 
     
     
         6 . The non-human transgenic animal of  claim 1 , wherein the animal has increased body ma    
     
     
         7 . A method of increasing body mass and/or body size of a livestock comprising:
 administering to the livestock an effective amount of GPR101 agonist, or a GPR01 protein, thereby increasing body mass and/or body size of the livestock.   
     
     
         8 . The method according to  claim 7 , wherein the livestock is a chicken, a goose, a duck, a turkey, a pheasant, a pig, a cow, a sheep, or a goat. 
     
     
         9 . The method of  claim 7 , wherein the method increases body mass of the livestock. 
     
     
         10 . The method of  claim 7 , wherein the method increases body size of the livestock.