Method and compositions for solubilizing non-polar constituents

Abstract

A method for solubilizing non-polar target compounds into a carrier liquid is described. A carrier oil, such as a MCT, or a mixture of MCTs, may be used to solubilize non-polar target compounds. The carrier oil may also include one or more buffers for stability of the target compounds within the carrier oil.

1 .- 22 . (canceled) 
     
     
         23 . A method for solubilizing a diterpene, the method comprising:
 admixing the diterpene and a medium chain triglyceride carrier liquid comprised of at least one of 0-6.0% of the triglyceride form of hexanoic acid, 6.0-60% of the triglyceride form of octanic acid, and 6.0-60% of the triglyceride form of decanoic acid to form an azeotropic solution;   adding an amount of buffer to the carrier liquid; and   heating the azeotropic solution in a heated vaporization delivery system to vaporize the azeotropic solution.   
     
     
         24 . The method of  claim 23 , wherein the carrier liquid and the diterpene are mixed in a ratio of about 50:50 v/v. 
     
     
         25 . The method of  claim 23 , wherein the method further comprises adding an amount of acid to the carrier liquid. 
     
     
         26 . The method of  claim 23 , wherein the method further comprises adding an amount of two or more buffers to the carrier liquid. 
     
     
         27 . The method of  claim 23 , wherein the buffer has a molar concentration of around 0.01-10 mM in the carrier liquid. 
     
     
         28 . The method of  claim 23 , wherein the carrier liquid and the diterpene are mixed in a ratio of about 0.01:99.99 v/v. 
     
     
         29 . The method of  claim 23 , wherein the carrier liquid and the diterpene are mixed in a ratio of about 95:5 v/v. 
     
     
         30 . The method of  claim 23 , wherein admixing the medium chain triglyceride carrier liquid and the diterpene forms an azeotropic mixture, wherein the carrier liquid and the diterpene are mixed in a ratio of about 50:50 v/v, and wherein the method further comprises adding at least one buffer to the carrier liquid, wherein the at least one buffer a molar concentration of around 0.01-10 mM in the carrier liquid. 
     
     
         31 . The method of  claim 30 , further comprising the step of adding an oil miscible anti-oxidant to the carrier liquid. 
     
     
         32 . The method of  claim 23 , wherein the diterpene comprises tetrahydracanabinol. 
     
     
         33 . A composition for use in an electronic nicotine delivery system, the composition comprising:
 a non-polar target compound, the non-polar target compound comprising a diterpene;   a carrier liquid comprised of one or more medium chain triglycerides comprised of at least one of about 0-6.0% of the triglyceride form of hexanoic acid, about 6.0-60% of the triglyceride form of octanic acid, and about 6.0-60% of the triglyceride form of decanoic acid; and   at least one buffer having a molar concentration of around 0.01-10 mM in the carrier liquid.   
     
     
         34 . The composition of  claim 33 , wherein the diterpene comprises tetrahydracanabinol. 
     
     
         35 . The composition of  claim 33 , wherein the composition comprises approximately 40 to 60 percent non-polar target compound and 40 to 60 percent carrier liquid. 
     
     
         36 . The composition of  claim 33 , wherein the carrier liquid comprises a mixture of at least two or more of the triglyceride forms of: hexanoic acid, octanic acid, decanoic acid, and dodecanoic acid. 
     
     
         37 . The composition of  claim 33 , wherein the composition comprises an azeotropic mixture having an azeotropic temperature of vaporization, and wherein the azeotropic temperature of vaporization is lower than a temperature of vaporization of the non-polar target compound and lower than a temperature of vaporization of carrier liquid. 
     
     
         38 . The composition of  claim 37 , wherein the composition comprises approximately 40 to 60 percent diterpene and 40 to 60 percent carrier liquid, and wherein the carrier liquid comprises an azeotropic mixture of the medium chain triglyceride carrier liquid. 
     
     
         39 . The composition of  claim 33 , further comprising an oil miscible anti-oxidant. 
     
     
         40 . A vapor cartridge for use in a heated vaporization system, the vapor cartridge containing a composition comprising;
 a non-polar target compound, the non-polar target compound comprising a diterpene;   at least one buffer; and   a carrier liquid comprised of one or more medium chain triglycerides comprised of at least one of the triglyceride forms of 0-6.0% hexanoic acid, 6.0-60% octanic acid, and 6.0-60% decanoic acid.   
     
     
         41 . The vapor cartridge of  claim 40 , further comprising an oil miscible anti-oxidant. 
     
     
         42 . The vapor cartridge of  claim 40 , wherein the diterpene comprises tetrahydracanabinol.