Compositions for and methods of diet supplementation

Abstract

A composition for diet supplementation to improve gut microflora is disclosed. The composition includes a prebiotic source and source of nucleotides, such as an extract of yeast. Also disclosed are methods of diet supplementation that include administering compositions of the invention to an individual.

1 . A composition for diet supplementation to improve gut microflora, comprising a prebiotic source and a nucleotide source. 
     
     
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         12 . The method of  claim 13 , wherein the composition further comprises an additional component selected from the group consisting of carbohydrates, proteins, polyunsaturated fatty acids, antioxidants, glutamine, ginseng, echinacea, probiotics, bovine colostrum, immunoferon, zinc, plant sterols, non-steroidal anti-inflammatory compounds and combinations thereof. 
     
     
         13 . A method of diet supplementation, comprising administering to an individual a serving of supplement in the form of capsules on a daily basis, wherein the serving comprises:
 an isolated prebiotic source, comprising a composition selected from the group consisting of inulin, galactooligosaccharides, xylooligosaccharides,   
       fructooligosaccharides and combinations thereof, present in an amount greater than about 0.5 g, and
 an isolated nucleotide source, comprising adenosine monophosphate, guanosine monophosphate, cytidine monophosphate, and uridine monophosphate, in an amount greater than about 100 mg. 
 
     
     
         14 . The method of  claim 13 , wherein the gut microflora of the individual is improved by administration of the supplement. 
     
     
         15 . The method of  claim 13 , wherein the lymphoid tissue associated with the gut mucosa of the individual is stimulated to produce antibodies to one or more pathogen by administration of the supplement. 
     
     
         16 . The method of  claim 13 , wherein the individual has an improvement in the incidence of upper respiratory infections as compared to the incidence of upper respiratory infections of that individual prior to the method of diet supplementation. 
     
     
         17 . The method of  claim 13 , wherein the individual has an improvement in immune system markers as compared to immune system markers in the individual prior to the method of diet supplementation. 
     
     
         18 . The method of  claim 13 , wherein the individual is an athlete. 
     
     
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         21 . The method of  claim 13 , wherein the individual is an athlete. 
     
     
         22 . The method of  claim 13 , wherein the prebiotic source is present in an amount greater than about 1 g. 
     
     
         23 . The method of  claim 13 , wherein the isolated nucleotide source is present in an amount between about 10 mg and about 300 mg. 
     
     
         24 . The method of  claim 13 , wherein the composition further comprises probiotic. 
     
     
         25 . The method of  claim 13 , wherein the isolated prebiotic source comprises xylooligosaccharides. 
     
     
         26 . A method of diet supplementation, comprising administering to an individual a serving of supplement in the form of capsules on a daily basis, wherein the serving comprises:
 an isolated prebiotic source comprising xylooligosaccharides present in an amount greater than about 0.5 g;   an isolated nucleotide source, comprising adenosine monophosphate, guanosine monophosphate, cytidine monophosphate, and uridine monophosphate, in an amount greater than about 100 mg; and   a probiotic.