Systems and method for detecting, diagnosing, and/or treatment of disorders and conditions

Abstract

A SoC includes an AFE to receive a plurality of differential input channels and generate digitized data corresponding to the channels, and a classification processor configured to receive the digitized data from the AFE. The AFE includes a Dual-Channel Chopper to perform channel multiplexing of two channels while simultaneously chopping the channels, a Dual Channel Charge Recycled-AFE having an Chopper-Stabilized Capacitive-Coupled IA including bias sampling capacitors that store bias values associated with the first and second channels to enable swapping between the channel, and a DC servo loop (DSL) having a reduced setting time based on a reduction in a resistance of the pseudo-PMOS in response to engaging a system reset. The classification processor includes a Frequency-Time Division Multiplexing (FTDM) Feature Extraction (FE) engine and a Dual-Detector Architecture (D2A) classification processor. The FTDM-FE includes a plurality of FIFOs configured to store, in parallel, the digitized data corresponding to the channels, a plurality of BPF banks storing BPF coefficients, and a single BPF to calculate outputs of one specific bank of the BFP banks for all of the channels. The D2A processor receives the output from the FTDM-FE and estimates a beginning and end of a seizure using two LSVMs optimized for only sensitivity and specificity, respectively.

What is claimed is: 
     
         1 . Skin-electrode impedance variation adaptation circuitry comprising:
 stimulation signal circuitry to generate electrical stimulating pulses to be applied to a patient's skin through one or more electrodes, said stimulation signal circuitry configured to generate said electrical stimulating pulses based on said electrical stimulating pulses such that said stimulation signal circuitry automatically adapts a number of pulses with respect to skin-electrode impedance variation to ensure constant charge delivery.   
     
     
         2 . The skin-electrode impedance variation adaptation circuitry of  claim 1 , wherein said stimulation signal circuitry is configured to monitor said naturally occurring RC time constant from said electrical stimulating pulses to determine information related to skin-electrode impedance. 
     
     
         3 . The skin-electrode impedance variation adaptation circuitry of  claim 1 , wherein said stimulation signal circuitry includes transcranial electrical stimulation (tES). 
     
     
         4 . The skin-electrode impedance variation adaptation circuitry of  claim 2 , wherein said skin-electrode impedance variation adaptation circuitry does not include current injecting circuitry for impedance monitoring.