Methods of treating epilepsy or status epilepticus

Abstract

Described herein are methods of treating epilepsy or status epilepticus, e.g., convulsive status epilepticus, e.g., early status epilepticus, established status epilepticus, refractory status epilepticus, super-refractory status epilepticus, e.g., super-refractory generalized status epilepticus; non-convulsive status epilepticus, e.g., generalized status epilepticus, complex partial status epilepticus; generalized periodic epileptiform discharges; periodic lateralized epileptiform discharges; a seizure, e.g., acute repetitive seizures, cluster seizures, the method comprising administering to the subject a neuroactive steroid.

1 - 164 . (canceled) 
     
     
         165 . A method of preparing a formulation comprising allopregnanolone, said method comprising the step of high shear mixing an aqueous 5 mg/mL solution of allopregnanolone with 25% sulfo butyl ether beta-cyclodextrin solution. 
     
     
         166 . The method of  claim 165 , wherein the step of high shear mixing is performed for a period of time, characterized by a clear aqueous solution comprising 5 mg/mL allopregnanolone and 25% sulfo butyl ether beta-cyclodextrin. 
     
     
         167 . The method of  claim 166 , where the period of time is at least about 30 minutes.