Assisted manual injector devices and methods

Abstract

Various embodiments disclosed herein relate to needle-based injectors that incorporate a power assembly comprising a stored energy source and a rate control assembly. The power assembly may be further configured to allow the injection to be performed with more force than a user may be capable of delivering, while also allowing the user to maintain control of the injection process after the stored energy source has been released and the injection has begun, such the user may increase or decrease the rate of injection, or stop the injection, during the injection process. In various embodiments, the power assembly may comprise spring- or gas-based stored energy sources, and/or may comprise friction- or tension-based rate control assemblies. Described herein are also methods for injecting an agent using embodiments of the devices described here.

1 . A device for injecting an agent, comprising:
 a syringe comprising a syringe cavity, a plunger element slidably received in the syringe cavity, and a hollow needle in fluid communication with the syringe cavity, wherein the plunger element is configured to move from a proximal position to a distal position;   a power assembly configured to transmit force to the plunger element; and   a user-actuated brake assembly that is configured to reversibly resist movement of the plunger element in at least one intermediate position between the proximal position and the distal position.   
     
     
         2 . The device of  claim 1 , wherein the brake assembly is biased to resist movement of the plunger element when in an inactivated state, and permits movement of the plunger element when in an activated state. 
     
     
         3 . The device of  claim 2 , wherein the brake assembly is biased by a brake spring to resist movement of the plunger element. 
     
     
         4 . The device of  claim 1 , wherein the power assembly comprises a mechanical spring. 
     
     
         5 . The device of  claim 1 , wherein the plunger element is further configured to simultaneously receive user-applied force that moves the plunger element toward the distal position. 
     
     
         6 . The device of  claim 1 , further comprising a housing wherein the syringe is located in the housing. 
     
     
         7 . The device of  claim 6 , wherein the housing is coupled to the plunger element. 
     
     
         8 . The device of  claim 7 , wherein the housing is configured to transmit user-applied force to the plunger element. 
     
     
         9 . The device of  claim 1 , wherein the brake assembly comprises a flexible, elongate brake cord. 
     
     
         10 . The device of  claim 9 , wherein the brake cord provides a releasable friction fit to reversibly resist movement of the plunger element. 
     
     
         11 . The device of  claim 10 , wherein the releasable friction fit is provided by releasable tension in the brake cord. 
     
     
         12 . The device of  claim 1 , wherein the brake assembly comprises a rigid friction element. 
     
     
         13 . The device of  claim 1 , wherein the brake assembly acts on an outer surface of the syringe to reversibly resist movement of the plunger element. 
     
     
         14 . The device of  claim 1 , wherein the brake assembly acts on a surface fixed relative to the syringe to reversibly resist movement of the plunger element. 
     
     
         15 . The device of  claim 1 , wherein the brake assembly comprises an opening in which the syringe resides. 
     
     
         16 . The device of  claim 1 , wherein the power assembly is configured to pull the plunger element toward the distal position. 
     
     
         17 . The device of  claim 1 , wherein the power assembly is configured to push the plunger element toward the distal position. 
     
     
         18 . The device of  claim 16 , wherein the power assembly is further configured to push and pull the plunger element toward the distal position. 
     
     
         19 . The device of  claim 6 , wherein the syringe is slidably located in the housing and the syringe is configured to move from a retracted position where a distal tip of the needle lies within the housing, toward an extended position where the distal tip of the needle extends distal to the housing. 
     
     
         20 . The device of  claim 1 , further comprising an extendable needle shroud, wherein the needle shroud is configured with a releasably locked, retracted state relative to the syringe, and an unlocked state that permits movement toward an extended position relative to the syringe. 
     
     
         21 . The device of  claim 19 , further comprising an extendable needle shroud, wherein the needle shroud is configured with a releasably locked, retracted state relative to the syringe, and an unlocked state that permits movement toward an extended position relative to the syringe, and wherein the needle shroud is further configured to change to the unlocked state before the distal tip of the needle extends distal to the housing. 
     
     
         22 . The device of  claim 21 , wherein the needle shroud is further configured to relock when the needle shroud reaches the extended state. 
     
     
         23 - 81 . (canceled) 
     
     
         82 . A device for injecting an agent, comprising:
 a housing having a longitudinal axis;   a syringe containing the agent within a syringe cavity, wherein the syringe is located within the housing;   a plunger slidable within the syringe, configured to be moveable between a proximal position and a distal position, wherein moving the plunger toward the distal position displaces the agent from the syringe; and   a spring in contact with the plunger configured to bias the plunger toward the distal position,   wherein the plunger comprises a braking pad configured to be reversibly moveable between a first configuration and a second configuration, wherein the braking pad generates friction to resist movement of the plunger in the second configuration.   
     
     
         83 . The device of  claim 82 , wherein the braking pad is configured to be moveable from the first configuration to the second configuration by radially outward movement. 
     
     
         84 . The device  claim 82 , further comprising a stopper located within the plunger and movable between a proximal position and a distal position within the plunger, wherein the stopper is configured such that moving the stopper from the distal position to the proximal position moves the braking pad from the first configuration to the second configuration. 
     
     
         85 . The device of  claim 84 , wherein the stopper is biased toward the proximal position. 
     
     
         86 . The device of  claim 84 , wherein the stopper is configured to be moveable between the proximal position and distal position by application of distal force on the housing. 
     
     
         87 . The device of  claim 82 , further comprising a retractable needle shroud configured to be moveable between a retracted position and an extended position. 
     
     
         88 . The device of  claim 82 , further comprising an end-of-dose indicator moveable between an inactivated and an activated configuration. 
     
     
         89 . (canceled) 
     
     
         90 . The device of  claim 1 , further comprising an extendable needle shroud, wherein the needle shroud is configured with an unlocked extended state that permits movement toward a retracted position relative to the syringe and a locked extended state. 
     
     
         91 . The device of  claim 90 , wherein the needle shroud is configured to enter the locked extended state when the needle shroud extends from a retracted state.