Prophylaxis and mitigation of migraine headaches using medium chain triglycerides, ketone ester, and other ketonic sources

Abstract

A composition comprising a dietary ketone, wherein the dietary ketone is designed to reduce migraine symptoms in a patient experiencing migraines and related method of manufacture and use are also disclosed.

What is claimed is: 
     
         1 . A composition comprising a dietary ketone, said dietary ketone is designed to reduce migraine symptoms in a patient experiencing migraines. 
     
     
         2 . The composition of  claim 1  wherein said dietary ketone is selected from a group consisting essentially of ketones, ketone esters, ketone salts and combinations thereof. 
     
     
         3 . The composition of  claim 1  wherein said dietary ketone is designed to prevent the onset of migraines in a patient with a history of migraines. 
     
     
         4 . The composition of  claim 1  wherein said dietary ketone is given to a patient in an amount sufficient to raise plasma ketone bodies to a level from about 2 mM to about 5 mM. 
     
     
         5 . The composition of  claim 1  wherein said dietary ketone is selected from a group consisting essentially of 3-hydroxybutyrate-1, 3-butanediol monoester, glyceryl-tris-3-hydroxybutyrate, R-3-hydroxybutyrate-R-1, 3-butanediol monoester and D-13-hydroxybutyrate-(R)-1,3-butanediol and mixtures and combinations thereof. 
     
     
         6 . The composition of  claim 1  wherein said dietary ketone is provided to a patient in an amount sufficient to reduce the symptoms of migraines. 
     
     
         7 . The composition of  claim 2  wherein said dietary ketone is provided to a patient in an amount sufficient to prevent the onset of migraines. 
     
     
         8 . A method of reducing migraine symptoms, said method comprises providing a patient with dietary ketones designed to reduce migraine symptoms in a patient experiencing migraines. 
     
     
         9 . The method of  claim 8  wherein said dietary ketone is selected from a group consisting essentially of ketones, ketone esters, ketone salts and combinations thereof. 
     
     
         10 . The method of  claim 8  wherein said dietary ketone is designed to prevent the onset of migraines in a patient with a history of migraines. 
     
     
         11 . The method of  claim 10  wherein said dietary ketone is provided to a patient in an amount sufficient to prevent the onset of migraines. 
     
     
         12 . The method of  claim 8  wherein said dietary ketone is given to a patient in an amount sufficient to raise plasma ketone bodies to a level from about 2 mM to about 5 mM. 
     
     
         13 . The method of  claim 8  wherein said dietary ketone is provided to a patient in an amount sufficient to reduce the symptoms of migraines. 
     
     
         14 . The method of  claim 8  wherein said dietary ketone is selected from a group consisting essentially of 3-hydroxybutyrate-1, 3-butanediol monoester, glyceryl-tris-3-hydroxybutyrate, R-3-hydroxybutyrate-R-1, 3-butanediol monoester and D-13-hydroxybutyrate-(R)-1,3-butanediol and mixtures and combinations thereof. 
     
     
         15 . A method of manufacturing a composition for treatment of migraines, said method comprises admixing a dietary ketone with an agent to form a composition designed to reduce migraine symptoms in a patient experiencing migraines. 
     
     
         16 . The method of  claim 15  wherein said dietary ketone is designed to prevent the onset of migraines in a patient with a history of migraines. 
     
     
         17 . The method of  claim 15  wherein said dietary ketone is selected from a group consisting essentially of ketones, ketone esters, ketone salts and combinations thereof. 
     
     
         18 . The method of  claim 15  wherein said dietary ketone is given to a patient in an amount sufficient to raise plasma ketone bodies to a level from about 2 mM to about 5 mM. 
     
     
         19 . The method of  claim 15  wherein said dietary ketone is selected from a group consisting essentially of 3-hydroxybutyrate-1, 3-butanediol monoester, glyceryl-tris-3-hydroxybutyrate, R-3-hydroxybutyrate-R-1, 3-butanediol monoester and D-13-hydroxybutyrate-(R)-1,3-butanediol and mixtures and combinations thereof. 
     
     
         20 . The method of  claim 15  wherein said agent is selected from a group consisting of pharmaceutical agents, non-pharmaceutical agents, stabilizing agents and mixtures and combinations thereof.