Systems and methods for simulation of hemodialysis access and optimization

Abstract

Systems and methods are disclosed for simulating or optimizing hemodialysis access. One method includes receiving a patient-specific anatomic model of a patient's vasculature; computing a pre-treatment hemodynamic characteristic of a pre-treatment geometry of a portion of the anatomic model; simulating a post-treatment geometry of a vascular access in the portion of the anatomic model; computing a post-treatment hemodynamic characteristic of the post-treatment geometry of the portion of the anatomic model having the vascular access; and generating a representation of the pre-treatment hemodynamic characteristic or the post-treatment hemodynamic characteristic.

1 - 20 . (canceled) 
     
     
         21 . A computer-implemented method of simulating or optimizing hemodialysis access, the method comprising:
 receiving a patient-specific anatomic model of a patient's vasculature;   modifying the geometry of the received patient-specific anatomic model such that the geometry of the received patient-specific anatomic model defines a post-treatment geometry of a vascular access;   determining a computational model of a hemodynamic characteristic of the modified anatomic model;   computing a post-treatment hemodynamic characteristic using the determined computational model; and   outputting or generating a representation of the post-treatment hemodynamic characteristic.   
     
     
         22 . The computer-implemented method of  claim 21 , wherein the hemodynamic characteristic includes blood pressure, blood velocity, or cardiac output. 
     
     
         23 . The computer-implemented method of  claim 21 , further comprising:
 receiving or determining a geometry of a planned treatment defining the vascular access; and   modifying the received patient-specific anatomic model such that the post-treatment geometry is based on the geometry of the planned treatment.   
     
     
         24 . The computer-implemented method of  claim 23 , wherein the planned treatment includes a graft. 
     
     
         25 . The computer-implemented method of  claim 21 , further comprising:
 receiving or measuring one or more candidate locations of the received patient-specific anatomic model, wherein the portion of the received patient-specific anatomic model is selected from one of the one or more candidate locations.   
     
     
         26 . The computer-implemented method of  claim 21 , further comprising:
 defining a cost function for optimizing the vascular access; and   solving the cost function using the post-treatment hemodynamic characteristic.   
     
     
         27 . The computer-implemented method of  claim 21 , further comprising:
 receiving one or more infeasible surgical geometries for the hemodialysis access, and   computing the post-treatment hemodynamic characteristic using the one or more infeasible geometries as constraints for the simulating of the post-treatment geometry.   
     
     
         28 . The computer-implemented method of  claim 21 , further comprising:
 selecting a treatment or treatment location of the vascular access based on the post-treatment hemodynamic characteristic.   
     
     
         29 . A system for simulating or optimizing hemodialysis access, the system comprising:
 a data storage device storing instructions for simulating or optimizing hemodialysis access; and   a processor configured to execute the instructions to perform a method including:
 receiving a patient-specific anatomic model of a patient's vasculature; 
 modifying the geometry of the received patient-specific anatomic model such that the geometry of the received patient-specific anatomic model defines a post-treatment geometry of a vascular access; 
 determining a computational model of a hemodynamic characteristic of the modified anatomic model; 
 computing a post-treatment hemodynamic characteristic using the determined computational model; and 
 outputting or generating a representation of the post-treatment hemodynamic characteristic. 
   
     
     
         30 . The system of  claim 29 , wherein the hemodynamic characteristic includes blood pressure, blood velocity, or cardiac output. 
     
     
         31 . The system of  claim 29 , wherein the system is further configured for:
 receiving or determining a geometry of a planned treatment defining the vascular access; and   modifying the received patient-specific anatomic model such that the post-treatment geometry is based on the geometry of the planned treatment.   
     
     
         32 . The system of  claim 31 , wherein the planned treatment includes a graft. 
     
     
         33 . The system of  claim 29 , wherein the system is further configured for:
 receiving or measuring one or more candidate locations of the received patient-specific anatomic model, wherein the portion of the received patient-specific anatomic model is selected from one of the one or more candidate locations.   
     
     
         34 . The system of  claim 29 , wherein the system is further configured for:
 defining a cost function for optimizing the vascular access; and   solving the cost function using the post-treatment hemodynamic characteristic.   
     
     
         35 . The system of  claim 29 , wherein the system is further configured for:
 receiving one or more infeasible surgical geometries for the hemodialysis access, and   computing the post-treatment hemodynamic characteristic using the one or more infeasible geometries as constraints for the simulating of the post-treatment geometry.   
     
     
         36 . The system of  claim 29 , wherein the system is further configured for:
 selecting a treatment or treatment location of the vascular access based on the post-treatment hemodynamic characteristic.   
     
     
         37 . A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method of simulating or optimizing hemodialysis access, the method comprising:
 receiving a patient-specific anatomic model of a patient's vasculature;   modifying the geometry of the received patient-specific anatomic model such that the geometry of the received patient-specific anatomic model defines a post-treatment geometry of a vascular access;   determining a computational model of a hemodynamic characteristic of the modified anatomic model;   computing a post-treatment hemodynamic characteristic using the determined computational model; and   outputting or generating a representation of the post-treatment hemodynamic characteristic.   
     
     
         38 . The non-transitory computer readable medium of  claim 37 , wherein the hemodynamic characteristic includes blood pressure, blood velocity, or cardiac output. 
     
     
         39 . The non-transitory computer readable medium of  claim 37 , the method further comprising:
 receiving or determining a geometry of a planned treatment defining the vascular access; and   modifying the received patient-specific anatomic model such that the post-treatment geometry is based on the geometry of the planned treatment.   
     
     
         40 . The non-transitory computer readable medium of  claim 39 , wherein the planned treatment includes a graft.